Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1287315..1287817 Replicon chromosome
Accession NZ_CP124420
Organism Escherichia coli strain AVS0155

Toxin (Protein)


Gene name yoeB Uniprot ID E2QNP2
Locus tag QJP63_RS06795 Protein ID WP_000767819.1
Coordinates 1287315..1287569 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID E2QNP3
Locus tag QJP63_RS06800 Protein ID WP_001259253.1
Coordinates 1287566..1287817 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP63_RS06770 (1283133) 1283133..1283591 - 459 WP_001531805.1 IS200/IS605-like element IS200C family transposase -
QJP63_RS06775 (1283808) 1283808..1285166 - 1359 WP_000019194.1 putrescine/proton symporter PlaP -
QJP63_RS06780 (1285156) 1285156..1285218 - 63 WP_010723108.1 membrane protein YoeI -
QJP63_RS06785 (1285433) 1285433..1286362 - 930 WP_000803366.1 LysR substrate-binding domain-containing protein -
QJP63_RS06790 (1286408) 1286408..1287232 - 825 WP_000754737.1 SDR family oxidoreductase -
QJP63_RS06795 (1287315) 1287315..1287569 - 255 WP_000767819.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
QJP63_RS06800 (1287566) 1287566..1287817 - 252 WP_001259253.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
QJP63_RS06805 (1288100) 1288100..1288150 + 51 WP_001364200.1 his operon leader peptide -
QJP63_RS06810 (1288296) 1288296..1289195 + 900 WP_000131782.1 ATP phosphoribosyltransferase -
QJP63_RS06815 (1289201) 1289201..1290505 + 1305 WP_001296211.1 histidinol dehydrogenase -
QJP63_RS06820 (1290502) 1290502..1291572 + 1071 WP_000108967.1 histidinol-phosphate transaminase -
QJP63_RS06825 (1291572) 1291572..1292639 + 1068 WP_000080057.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1283133..1283591 458


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10110.53 Da        Isoelectric Point: 7.2749

>T280157 WP_000767819.1 NZ_CP124420:c1287569-1287315 [Escherichia coli]
VKLIWSEESWDDYLYWQEADKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHLLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9365.62 Da        Isoelectric Point: 4.6127

>AT280157 WP_001259253.1 NZ_CP124420:c1287817-1287566 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSDKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E2QNP2

Antitoxin

Source ID Structure
AlphaFold DB E2QNP3

References