Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 2080798..2081597 Replicon chromosome
Accession NZ_CP124415
Organism Escherichia coli strain AVS0223

Toxin (Protein)


Gene name yhaV Uniprot ID S1NYM6
Locus tag QJP60_RS10025 Protein ID WP_000347251.1
Coordinates 2081133..2081597 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1PPV5
Locus tag QJP60_RS10020 Protein ID WP_001296435.1
Coordinates 2080798..2081133 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP60_RS10005 (2076583) 2076583..2077353 - 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -
QJP60_RS10010 (2077369) 2077369..2078703 - 1335 WP_000599651.1 galactarate/glucarate/glycerate transporter GarP -
QJP60_RS10015 (2079078) 2079078..2080649 + 1572 WP_001273763.1 galactarate dehydratase -
QJP60_RS10020 (2080798) 2080798..2081133 + 336 WP_001296435.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
QJP60_RS10025 (2081133) 2081133..2081597 + 465 WP_000347251.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
QJP60_RS10030 (2081652) 2081652..2082461 - 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
QJP60_RS10035 (2082710) 2082710..2083990 + 1281 WP_000681950.1 tagatose-bisphosphate aldolase subunit KbaZ -
QJP60_RS10040 (2084013) 2084013..2084486 + 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
QJP60_RS10045 (2084497) 2084497..2085276 + 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
QJP60_RS10050 (2085266) 2085266..2086144 + 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
QJP60_RS10055 (2086162) 2086162..2086596 + 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17777.14 Da        Isoelectric Point: 9.4947

>T280122 WP_000347251.1 NZ_CP124415:2081133-2081597 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12321.92 Da        Isoelectric Point: 4.5392

>AT280122 WP_001296435.1 NZ_CP124415:2080798-2081133 [Escherichia coli]
MPANARSNAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CJ20

Antitoxin

Source ID Structure
AlphaFold DB S1PPV5

References