Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 2899331..2899933 Replicon chromosome
Accession NZ_CP124410
Organism Escherichia coli strain AVS0543

Toxin (Protein)


Gene name higB Uniprot ID S1P416
Locus tag QJP61_RS14060 Protein ID WP_000897302.1
Coordinates 2899331..2899642 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QJP61_RS14065 Protein ID WP_000356397.1
Coordinates 2899643..2899933 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP61_RS14035 (2895245) 2895245..2895844 + 600 WP_001296610.1 glucose-1-phosphatase -
QJP61_RS14040 (2895838) 2895838..2896710 + 873 WP_000920762.1 virulence factor BrkB family protein -
QJP61_RS14045 (2896707) 2896707..2897144 + 438 WP_000560981.1 D-aminoacyl-tRNA deacylase -
QJP61_RS14050 (2897189) 2897189..2898130 + 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
QJP61_RS14055 (2898194) 2898194..2899102 - 909 WP_001385591.1 alpha/beta hydrolase -
QJP61_RS14060 (2899331) 2899331..2899642 + 312 WP_000897302.1 hypothetical protein Toxin
QJP61_RS14065 (2899643) 2899643..2899933 + 291 WP_000356397.1 NadS family protein Antitoxin
QJP61_RS14070 (2900292) 2900292..2900570 + 279 WP_001296612.1 hypothetical protein -
QJP61_RS14075 (2900967) 2900967..2901185 + 219 WP_001251293.1 CopG family transcriptional regulator -
QJP61_RS14080 (2901370) 2901370..2902110 - 741 WP_000608806.1 hypothetical protein -
QJP61_RS14085 (2902135) 2902135..2902983 - 849 WP_001038650.1 hypothetical protein -
QJP61_RS14090 (2903273) 2903273..2903515 + 243 WP_001068514.1 CopG family transcriptional regulator -
QJP61_RS14095 (2903697) 2903697..2904626 - 930 WP_000027696.1 formate dehydrogenase accessory protein FdhE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12203.19 Da        Isoelectric Point: 9.7791

>T280090 WP_000897302.1 NZ_CP124410:2899331-2899642 [Escherichia coli]
MLFIETEIFTEDVQKLLNDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT280090 WP_000356397.1 NZ_CP124410:2899643-2899933 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P416

Antitoxin

Source ID Structure

References