Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3782795..3783452 Replicon chromosome
Accession NC_018079
Organism Enterobacter cloacae subsp. dissolvens SDM

Toxin (Protein)


Gene name higB Uniprot ID A0A421IAD7
Locus tag A3UG_RS17690 Protein ID WP_014832979.1
Coordinates 3782795..3783094 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A427KGI2
Locus tag A3UG_RS17695 Protein ID WP_014832980.1
Coordinates 3783105..3783452 (+) Length 116 a.a.

Genomic Context

A3UG_RS17675A3UG_RS17680A3UG_RS24535A3UG_RS17685A3UG_RS17690A3UG_RS17695A3UG_RS17700A3UG_RS17710A3UG_RS17725A3UG_RS17705A3UG_RS17715A3UG_RS17720
Location: 3778401..3780593 (2193 bp)
Type: Others
Protein ID: WP_014832976.1
Location: 3780604..3781773 (1170 bp)
Type: Others
Protein ID: WP_126522669.1
Location: 3781965..3782079 (115 bp)
Type: Others
Protein ID: Protein_3471
Location: 3782101..3782538 (438 bp)
Type: Others
Protein ID: WP_014832978.1
Location: 3782795..3783094 (300 bp)
Type: Toxin
Protein ID: WP_014832979.1
Location: 3783105..3783452 (348 bp)
Type: Antitoxin
Protein ID: WP_014832980.1
Location: 3783498..3783923 (426 bp)
Type: Others
Protein ID: Protein_3475
Location: 3784725..3785144 (420 bp)
Type: Others
Protein ID: WP_014832984.1
Location: 3787419..3788021 (603 bp)
Type: Others
Protein ID: WP_014832987.1
Location: 3783895..3784626 (732 bp)
Type: Others
Protein ID: WP_014832983.1
Location: 3785233..3786414 (1182 bp)
Type: Others
Protein ID: WP_014832985.1
Location: 3786434..3787321 (888 bp)
Type: Others
Protein ID: WP_014832986.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
A3UG_RS176753778401..3780593+2193WP_014832976.1type I secretion system permease/ATPase-
A3UG_RS176803780604..3781773+1170WP_126522669.1HlyD family efflux transporter periplasmic adaptor subunit-
A3UG_RS245353781965..3782079+115Protein_3471ash family protein-
A3UG_RS176853782101..3782538+438WP_014832978.1hypothetical protein-
A3UG_RS176903782795..3783094+300WP_014832979.1type II toxin-antitoxin system RelE/ParE family toxinToxin
A3UG_RS176953783105..3783452+348WP_014832980.1HigA family addiction module antidote proteinAntitoxin
A3UG_RS177003783498..3783923+426Protein_3475nucleoside triphosphatase NudI-
A3UG_RS177053783895..3784626-732WP_014832983.1helix-turn-helix transcriptional regulator-
A3UG_RS177103784725..3785144+420WP_014832984.1nuclear transport factor 2 family protein-
A3UG_RS177153785233..3786414-1182WP_014832985.1PLP-dependent aminotransferase family protein-
A3UG_RS177203786434..3787321-888WP_014832986.1LysR family transcriptional regulator-
A3UG_RS177253787419..3788021+603WP_014832987.1short chain dehydrogenase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(20-71)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11646.28 Da        Isoelectric Point: 10.0182

>T28009 WP_014832979.1 NC_018079:3782795-3783094 [Enterobacter cloacae subsp. dissolvens SDM]
MINHFRDQWLEDFFLYGRSSNVIPSNLETVLARKLDLINAAISHRDLRSPPGNMFEALNPPLKGYSSIRVNRQYRLVFRW
AEGKADDLYLSPHKYTQHK

Download         Length: 300 bp

>T28009 NC_018079:3782795-3783094 [Enterobacter cloacae subsp. dissolvens SDM]
ATGATTAATCATTTTCGGGATCAATGGCTTGAGGATTTTTTTCTTTACGGGAGATCGAGCAATGTTATTCCTTCAAATCT
GGAAACCGTTCTTGCAAGAAAGCTCGACCTCATCAATGCAGCCATCTCGCATCGGGATTTGCGTTCACCACCGGGCAATA
TGTTTGAAGCATTGAATCCGCCGCTGAAGGGATATTCCTCAATCCGGGTAAACAGACAATACAGGCTTGTATTTCGCTGG
GCAGAGGGAAAAGCAGACGATCTCTATCTCTCTCCACACAAGTACACGCAACACAAGTGA

Antitoxin


Download         Length: 116 a.a.        Molecular weight: 13066.11 Da        Isoelectric Point: 8.5158

>AT28009 WP_014832980.1 NC_018079:3783105-3783452 [Enterobacter cloacae subsp. dissolvens SDM]
MILQQALRKPTTPGDVLQYEYLEPLNLKISDLAEMLNVHRNTISALVNNNRKLTADMAIKLAKAFDTTIEFWLKLQLNVD
IWEAQSNSRTQEELSRIKTVAEVMAKRKGGQPDVA

Download         Length: 348 bp

>AT28009 NC_018079:3783105-3783452 [Enterobacter cloacae subsp. dissolvens SDM]
ATGATACTTCAACAGGCACTCCGCAAACCCACCACGCCGGGCGACGTGTTGCAATATGAGTATCTTGAACCGCTCAATCT
GAAAATCAGCGATCTGGCGGAGATGCTAAATGTACACCGCAATACCATCAGCGCGCTGGTAAATAACAATCGCAAGCTTA
CCGCCGATATGGCGATAAAATTGGCAAAAGCCTTTGATACCACTATTGAATTTTGGTTGAAATTACAACTGAACGTCGAT
ATCTGGGAAGCACAATCAAACTCCAGAACGCAAGAGGAGCTGAGCCGTATAAAAACCGTTGCGGAAGTCATGGCGAAGCG
TAAAGGTGGTCAACCGGATGTTGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A421IAD7

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A427KGI2

References