Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 2084601..2085400 Replicon chromosome
Accession NZ_CP124410
Organism Escherichia coli strain AVS0543

Toxin (Protein)


Gene name yhaV Uniprot ID S1NYM6
Locus tag QJP61_RS10065 Protein ID WP_000347251.1
Coordinates 2084936..2085400 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1PPV5
Locus tag QJP61_RS10060 Protein ID WP_001296435.1
Coordinates 2084601..2084936 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP61_RS10045 (2080386) 2080386..2081156 - 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -
QJP61_RS10050 (2081172) 2081172..2082506 - 1335 WP_000599651.1 galactarate/glucarate/glycerate transporter GarP -
QJP61_RS10055 (2082881) 2082881..2084452 + 1572 WP_001273763.1 galactarate dehydratase -
QJP61_RS10060 (2084601) 2084601..2084936 + 336 WP_001296435.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
QJP61_RS10065 (2084936) 2084936..2085400 + 465 WP_000347251.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
QJP61_RS10070 (2085455) 2085455..2086264 - 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
QJP61_RS10075 (2086513) 2086513..2087793 + 1281 WP_000681950.1 tagatose-bisphosphate aldolase subunit KbaZ -
QJP61_RS10080 (2087816) 2087816..2088289 + 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
QJP61_RS10085 (2088300) 2088300..2089079 + 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
QJP61_RS10090 (2089069) 2089069..2089947 + 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
QJP61_RS10095 (2089965) 2089965..2090399 + 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17777.14 Da        Isoelectric Point: 9.4947

>T280088 WP_000347251.1 NZ_CP124410:2084936-2085400 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12321.92 Da        Isoelectric Point: 4.5392

>AT280088 WP_001296435.1 NZ_CP124410:2084601-2084936 [Escherichia coli]
MPANARSNAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CJ20

Antitoxin

Source ID Structure
AlphaFold DB S1PPV5

References