Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 1996762..1997561 Replicon chromosome
Accession NZ_CP124405
Organism Escherichia coli strain AVS0935

Toxin (Protein)


Gene name yhaV Uniprot ID S1NYM6
Locus tag QJB05_RS09570 Protein ID WP_000347251.1
Coordinates 1997097..1997561 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1PPV5
Locus tag QJB05_RS09565 Protein ID WP_001296435.1
Coordinates 1996762..1997097 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJB05_RS09550 (1992547) 1992547..1993317 - 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -
QJB05_RS09555 (1993333) 1993333..1994667 - 1335 WP_000599651.1 galactarate/glucarate/glycerate transporter GarP -
QJB05_RS09560 (1995042) 1995042..1996613 + 1572 WP_001273763.1 galactarate dehydratase -
QJB05_RS09565 (1996762) 1996762..1997097 + 336 WP_001296435.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
QJB05_RS09570 (1997097) 1997097..1997561 + 465 WP_000347251.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
QJB05_RS09575 (1997616) 1997616..1998425 - 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
QJB05_RS09580 (1998674) 1998674..1999954 + 1281 WP_000681950.1 tagatose-bisphosphate aldolase subunit KbaZ -
QJB05_RS09585 (1999977) 1999977..2000450 + 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
QJB05_RS09590 (2000461) 2000461..2001240 + 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
QJB05_RS09595 (2001230) 2001230..2002108 + 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
QJB05_RS09600 (2002126) 2002126..2002560 + 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17777.14 Da        Isoelectric Point: 9.4947

>T280053 WP_000347251.1 NZ_CP124405:1997097-1997561 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12321.92 Da        Isoelectric Point: 4.5392

>AT280053 WP_001296435.1 NZ_CP124405:1996762-1997097 [Escherichia coli]
MPANARSNAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CJ20

Antitoxin

Source ID Structure
AlphaFold DB S1PPV5

References