Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 789114..789616 Replicon chromosome
Accession NZ_CP124405
Organism Escherichia coli strain AVS0935

Toxin (Protein)


Gene name yoeB Uniprot ID E2QNP2
Locus tag QJB05_RS04055 Protein ID WP_000767819.1
Coordinates 789114..789368 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID E2QNP3
Locus tag QJB05_RS04060 Protein ID WP_001259253.1
Coordinates 789365..789616 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJB05_RS04030 (784932) 784932..785390 - 459 WP_001531805.1 IS200/IS605-like element IS200C family transposase -
QJB05_RS04035 (785607) 785607..786965 - 1359 WP_000019194.1 putrescine/proton symporter PlaP -
QJB05_RS04040 (786955) 786955..787017 - 63 WP_010723108.1 membrane protein YoeI -
QJB05_RS04045 (787232) 787232..788161 - 930 WP_000803366.1 LysR substrate-binding domain-containing protein -
QJB05_RS04050 (788207) 788207..789031 - 825 WP_000754737.1 SDR family oxidoreductase -
QJB05_RS04055 (789114) 789114..789368 - 255 WP_000767819.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
QJB05_RS04060 (789365) 789365..789616 - 252 WP_001259253.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
QJB05_RS04065 (789899) 789899..789949 + 51 WP_001364200.1 his operon leader peptide -
QJB05_RS04070 (790095) 790095..790994 + 900 WP_000131782.1 ATP phosphoribosyltransferase -
QJB05_RS04075 (791000) 791000..792304 + 1305 WP_001296211.1 histidinol dehydrogenase -
QJB05_RS04080 (792301) 792301..793371 + 1071 WP_000108967.1 histidinol-phosphate transaminase -
QJB05_RS04085 (793371) 793371..794438 + 1068 WP_000080057.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 784932..785390 458


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10110.53 Da        Isoelectric Point: 7.2749

>T280050 WP_000767819.1 NZ_CP124405:c789368-789114 [Escherichia coli]
VKLIWSEESWDDYLYWQEADKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHLLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9365.62 Da        Isoelectric Point: 4.6127

>AT280050 WP_001259253.1 NZ_CP124405:c789616-789365 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSDKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E2QNP2

Antitoxin

Source ID Structure
AlphaFold DB E2QNP3

References