Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 2885103..2885705 Replicon chromosome
Accession NZ_CP124400
Organism Escherichia coli strain AVS0528

Toxin (Protein)


Gene name higB Uniprot ID S1P416
Locus tag QJP80_RS13955 Protein ID WP_000897302.1
Coordinates 2885103..2885414 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QJP80_RS13960 Protein ID WP_000356397.1
Coordinates 2885415..2885705 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP80_RS13930 (2881017) 2881017..2881616 + 600 WP_001296610.1 glucose-1-phosphatase -
QJP80_RS13935 (2881610) 2881610..2882482 + 873 WP_000920762.1 virulence factor BrkB family protein -
QJP80_RS13940 (2882479) 2882479..2882916 + 438 WP_000560981.1 D-aminoacyl-tRNA deacylase -
QJP80_RS13945 (2882961) 2882961..2883902 + 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
QJP80_RS13950 (2883966) 2883966..2884874 - 909 WP_001385591.1 alpha/beta hydrolase -
QJP80_RS13955 (2885103) 2885103..2885414 + 312 WP_000897302.1 hypothetical protein Toxin
QJP80_RS13960 (2885415) 2885415..2885705 + 291 WP_000356397.1 NadS family protein Antitoxin
QJP80_RS13965 (2886064) 2886064..2886342 + 279 WP_001296612.1 hypothetical protein -
QJP80_RS13970 (2886739) 2886739..2886957 + 219 WP_001251293.1 CopG family transcriptional regulator -
QJP80_RS13975 (2887142) 2887142..2887882 - 741 WP_000608806.1 hypothetical protein -
QJP80_RS13980 (2887907) 2887907..2888755 - 849 WP_001038650.1 hypothetical protein -
QJP80_RS13985 (2889045) 2889045..2889287 + 243 WP_001068514.1 CopG family transcriptional regulator -
QJP80_RS13990 (2889469) 2889469..2890398 - 930 WP_000027696.1 formate dehydrogenase accessory protein FdhE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12203.19 Da        Isoelectric Point: 9.7791

>T280025 WP_000897302.1 NZ_CP124400:2885103-2885414 [Escherichia coli]
MLFIETEIFTEDVQKLLNDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT280025 WP_000356397.1 NZ_CP124400:2885415-2885705 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P416

Antitoxin

Source ID Structure

References