Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 2072405..2073204 Replicon chromosome
Accession NZ_CP124400
Organism Escherichia coli strain AVS0528

Toxin (Protein)


Gene name yhaV Uniprot ID S1NYM6
Locus tag QJP80_RS09980 Protein ID WP_000347251.1
Coordinates 2072740..2073204 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1PPV5
Locus tag QJP80_RS09975 Protein ID WP_001296435.1
Coordinates 2072405..2072740 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP80_RS09960 (2068190) 2068190..2068960 - 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -
QJP80_RS09965 (2068976) 2068976..2070310 - 1335 WP_000599651.1 galactarate/glucarate/glycerate transporter GarP -
QJP80_RS09970 (2070685) 2070685..2072256 + 1572 WP_001273763.1 galactarate dehydratase -
QJP80_RS09975 (2072405) 2072405..2072740 + 336 WP_001296435.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
QJP80_RS09980 (2072740) 2072740..2073204 + 465 WP_000347251.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
QJP80_RS09985 (2073259) 2073259..2074068 - 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
QJP80_RS09990 (2074317) 2074317..2075597 + 1281 WP_000681950.1 tagatose-bisphosphate aldolase subunit KbaZ -
QJP80_RS09995 (2075620) 2075620..2076093 + 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
QJP80_RS10000 (2076104) 2076104..2076883 + 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
QJP80_RS10005 (2076873) 2076873..2077751 + 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
QJP80_RS10010 (2077769) 2077769..2078203 + 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17777.14 Da        Isoelectric Point: 9.4947

>T280023 WP_000347251.1 NZ_CP124400:2072740-2073204 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12321.92 Da        Isoelectric Point: 4.5392

>AT280023 WP_001296435.1 NZ_CP124400:2072405-2072740 [Escherichia coli]
MPANARSNAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CJ20

Antitoxin

Source ID Structure
AlphaFold DB S1PPV5

References