Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 2947574..2948176 Replicon chromosome
Accession NZ_CP124387
Organism Escherichia coli strain AVS0972

Toxin (Protein)


Gene name higB Uniprot ID S1P416
Locus tag QJB01_RS14310 Protein ID WP_000897302.1
Coordinates 2947574..2947885 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QJB01_RS14315 Protein ID WP_000356397.1
Coordinates 2947886..2948176 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJB01_RS14285 (2943488) 2943488..2944087 + 600 WP_001296610.1 glucose-1-phosphatase -
QJB01_RS14290 (2944081) 2944081..2944953 + 873 WP_000920762.1 virulence factor BrkB family protein -
QJB01_RS14295 (2944950) 2944950..2945387 + 438 WP_000560981.1 D-aminoacyl-tRNA deacylase -
QJB01_RS14300 (2945432) 2945432..2946373 + 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
QJB01_RS14305 (2946437) 2946437..2947345 - 909 WP_001385591.1 alpha/beta hydrolase -
QJB01_RS14310 (2947574) 2947574..2947885 + 312 WP_000897302.1 hypothetical protein Toxin
QJB01_RS14315 (2947886) 2947886..2948176 + 291 WP_000356397.1 NadS family protein Antitoxin
QJB01_RS14320 (2948535) 2948535..2948813 + 279 WP_001296612.1 hypothetical protein -
QJB01_RS14325 (2949210) 2949210..2949428 + 219 WP_001251293.1 CopG family transcriptional regulator -
QJB01_RS14330 (2949613) 2949613..2950353 - 741 WP_000608806.1 hypothetical protein -
QJB01_RS14335 (2950378) 2950378..2951226 - 849 WP_001038650.1 hypothetical protein -
QJB01_RS14340 (2951516) 2951516..2951758 + 243 WP_001068514.1 CopG family transcriptional regulator -
QJB01_RS14345 (2951940) 2951940..2952869 - 930 WP_000027696.1 formate dehydrogenase accessory protein FdhE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12203.19 Da        Isoelectric Point: 9.7791

>T279993 WP_000897302.1 NZ_CP124387:2947574-2947885 [Escherichia coli]
MLFIETEIFTEDVQKLLNDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT279993 WP_000356397.1 NZ_CP124387:2947886-2948176 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P416

Antitoxin

Source ID Structure

References