Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 2080446..2081245 Replicon chromosome
Accession NZ_CP124387
Organism Escherichia coli strain AVS0972

Toxin (Protein)


Gene name yhaV Uniprot ID S1NYM6
Locus tag QJB01_RS10025 Protein ID WP_000347251.1
Coordinates 2080781..2081245 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1PPV5
Locus tag QJB01_RS10020 Protein ID WP_001296435.1
Coordinates 2080446..2080781 (+) Length 112 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJB01_RS10005 (2076231) 2076231..2077001 - 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -
QJB01_RS10010 (2077017) 2077017..2078351 - 1335 WP_000599651.1 galactarate/glucarate/glycerate transporter GarP -
QJB01_RS10015 (2078726) 2078726..2080297 + 1572 WP_001273763.1 galactarate dehydratase -
QJB01_RS10020 (2080446) 2080446..2080781 + 336 WP_001296435.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
QJB01_RS10025 (2080781) 2080781..2081245 + 465 WP_000347251.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
QJB01_RS10030 (2081300) 2081300..2082109 - 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
QJB01_RS10035 (2082358) 2082358..2083638 + 1281 WP_000681950.1 tagatose-bisphosphate aldolase subunit KbaZ -
QJB01_RS10040 (2083661) 2083661..2084134 + 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
QJB01_RS10045 (2084145) 2084145..2084924 + 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
QJB01_RS10050 (2084914) 2084914..2085792 + 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
QJB01_RS10055 (2085810) 2085810..2086244 + 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(12-150)

Antitoxin

(14-110)


Sequences


Toxin        


Download         Length: 155 a.a.        Molecular weight: 17777.14 Da        Isoelectric Point: 9.4947

>T279990 WP_000347251.1 NZ_CP124387:2080781-2081245 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp


Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12321.92 Da        Isoelectric Point: 4.5392

>AT279990 WP_001296435.1 NZ_CP124387:2080446-2080781 [Escherichia coli]
MPANARSNAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A829CJ20


Antitoxin

Source ID Structure
AlphaFold DB S1PPV5

References