Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 2242067..2242866 Replicon chromosome
Accession NZ_CP124385
Organism Escherichia coli strain AVS0153

Toxin (Protein)


Gene name yhaV Uniprot ID S1NYM6
Locus tag QJP67_RS11170 Protein ID WP_000347251.1
Coordinates 2242402..2242866 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1PPV5
Locus tag QJP67_RS11165 Protein ID WP_001296435.1
Coordinates 2242067..2242402 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP67_RS11150 (2237852) 2237852..2238622 - 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -
QJP67_RS11155 (2238638) 2238638..2239972 - 1335 WP_000599651.1 galactarate/glucarate/glycerate transporter GarP -
QJP67_RS11160 (2240347) 2240347..2241918 + 1572 WP_001273763.1 galactarate dehydratase -
QJP67_RS11165 (2242067) 2242067..2242402 + 336 WP_001296435.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
QJP67_RS11170 (2242402) 2242402..2242866 + 465 WP_000347251.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
QJP67_RS11175 (2242921) 2242921..2243730 - 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
QJP67_RS11180 (2243979) 2243979..2245259 + 1281 WP_000681950.1 tagatose-bisphosphate aldolase subunit KbaZ -
QJP67_RS11185 (2245282) 2245282..2245755 + 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
QJP67_RS11190 (2245766) 2245766..2246545 + 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
QJP67_RS11195 (2246535) 2246535..2247413 + 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
QJP67_RS11200 (2247431) 2247431..2247865 + 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17777.14 Da        Isoelectric Point: 9.4947

>T279958 WP_000347251.1 NZ_CP124385:2242402-2242866 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12321.92 Da        Isoelectric Point: 4.5392

>AT279958 WP_001296435.1 NZ_CP124385:2242067-2242402 [Escherichia coli]
MPANARSNAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CJ20

Antitoxin

Source ID Structure
AlphaFold DB S1PPV5

References