Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 5121143..5121745 Replicon chromosome
Accession NZ_CP124374
Organism Escherichia coli strain AVS0578

Toxin (Protein)


Gene name higB Uniprot ID S1P416
Locus tag QJP97_RS25200 Protein ID WP_000897302.1
Coordinates 5121143..5121454 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QJP97_RS25205 Protein ID WP_000356397.1
Coordinates 5121455..5121745 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP97_RS25175 (5117057) 5117057..5117656 + 600 WP_001296610.1 glucose-1-phosphatase -
QJP97_RS25180 (5117650) 5117650..5118522 + 873 WP_000920762.1 virulence factor BrkB family protein -
QJP97_RS25185 (5118519) 5118519..5118956 + 438 WP_000560981.1 D-aminoacyl-tRNA deacylase -
QJP97_RS25190 (5119001) 5119001..5119942 + 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
QJP97_RS25195 (5120006) 5120006..5120914 - 909 WP_001385591.1 alpha/beta hydrolase -
QJP97_RS25200 (5121143) 5121143..5121454 + 312 WP_000897302.1 hypothetical protein Toxin
QJP97_RS25205 (5121455) 5121455..5121745 + 291 WP_000356397.1 NadS family protein Antitoxin
QJP97_RS25210 (5122104) 5122104..5122382 + 279 WP_001296612.1 hypothetical protein -
QJP97_RS25215 (5122779) 5122779..5122997 + 219 WP_001251293.1 CopG family transcriptional regulator -
QJP97_RS25220 (5123182) 5123182..5123922 - 741 WP_000608806.1 hypothetical protein -
QJP97_RS25225 (5123947) 5123947..5124795 - 849 WP_001038650.1 hypothetical protein -
QJP97_RS25230 (5125085) 5125085..5125327 + 243 WP_001068514.1 CopG family transcriptional regulator -
QJP97_RS25235 (5125509) 5125509..5126438 - 930 WP_000027696.1 formate dehydrogenase accessory protein FdhE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12203.19 Da        Isoelectric Point: 9.7791

>T279939 WP_000897302.1 NZ_CP124374:5121143-5121454 [Escherichia coli]
MLFIETEIFTEDVQKLLNDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT279939 WP_000356397.1 NZ_CP124374:5121455-5121745 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P416

Antitoxin

Source ID Structure

References