Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 4243894..4244693 Replicon chromosome
Accession NZ_CP124374
Organism Escherichia coli strain AVS0578

Toxin (Protein)


Gene name yhaV Uniprot ID S1NYM6
Locus tag QJP97_RS20925 Protein ID WP_000347251.1
Coordinates 4244229..4244693 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1PPV5
Locus tag QJP97_RS20920 Protein ID WP_001296435.1
Coordinates 4243894..4244229 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP97_RS20905 (4239679) 4239679..4240449 - 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -
QJP97_RS20910 (4240465) 4240465..4241799 - 1335 WP_000599651.1 galactarate/glucarate/glycerate transporter GarP -
QJP97_RS20915 (4242174) 4242174..4243745 + 1572 WP_001273763.1 galactarate dehydratase -
QJP97_RS20920 (4243894) 4243894..4244229 + 336 WP_001296435.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
QJP97_RS20925 (4244229) 4244229..4244693 + 465 WP_000347251.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
QJP97_RS20930 (4244748) 4244748..4245557 - 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
QJP97_RS20935 (4245806) 4245806..4247086 + 1281 WP_000681950.1 tagatose-bisphosphate aldolase subunit KbaZ -
QJP97_RS20940 (4247109) 4247109..4247582 + 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
QJP97_RS20945 (4247593) 4247593..4248372 + 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
QJP97_RS20950 (4248362) 4248362..4249240 + 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
QJP97_RS20955 (4249258) 4249258..4249692 + 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17777.14 Da        Isoelectric Point: 9.4947

>T279936 WP_000347251.1 NZ_CP124374:4244229-4244693 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12321.92 Da        Isoelectric Point: 4.5392

>AT279936 WP_001296435.1 NZ_CP124374:4243894-4244229 [Escherichia coli]
MPANARSNAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CJ20

Antitoxin

Source ID Structure
AlphaFold DB S1PPV5

References