Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2990316..2990818 Replicon chromosome
Accession NZ_CP124374
Organism Escherichia coli strain AVS0578

Toxin (Protein)


Gene name yoeB Uniprot ID E2QNP2
Locus tag QJP97_RS15150 Protein ID WP_000767819.1
Coordinates 2990316..2990570 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID E2QNP3
Locus tag QJP97_RS15155 Protein ID WP_001259253.1
Coordinates 2990567..2990818 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP97_RS15125 (2986134) 2986134..2986592 - 459 WP_001531805.1 IS200/IS605-like element IS200C family transposase -
QJP97_RS15130 (2986809) 2986809..2988167 - 1359 WP_000019194.1 putrescine/proton symporter PlaP -
QJP97_RS15135 (2988157) 2988157..2988219 - 63 WP_010723108.1 membrane protein YoeI -
QJP97_RS15140 (2988434) 2988434..2989363 - 930 WP_000803366.1 LysR substrate-binding domain-containing protein -
QJP97_RS15145 (2989409) 2989409..2990233 - 825 WP_000754737.1 SDR family oxidoreductase -
QJP97_RS15150 (2990316) 2990316..2990570 - 255 WP_000767819.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
QJP97_RS15155 (2990567) 2990567..2990818 - 252 WP_001259253.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
QJP97_RS15160 (2991101) 2991101..2991151 + 51 WP_001364200.1 his operon leader peptide -
QJP97_RS15165 (2991297) 2991297..2992196 + 900 WP_000131782.1 ATP phosphoribosyltransferase -
QJP97_RS15170 (2992202) 2992202..2993506 + 1305 WP_001296211.1 histidinol dehydrogenase -
QJP97_RS15175 (2993503) 2993503..2994573 + 1071 WP_000108967.1 histidinol-phosphate transaminase -
QJP97_RS15180 (2994573) 2994573..2995640 + 1068 WP_000080057.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2986134..2986592 458


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10110.53 Da        Isoelectric Point: 7.2749

>T279932 WP_000767819.1 NZ_CP124374:c2990570-2990316 [Escherichia coli]
VKLIWSEESWDDYLYWQEADKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHLLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9365.62 Da        Isoelectric Point: 4.6127

>AT279932 WP_001259253.1 NZ_CP124374:c2990818-2990567 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSDKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E2QNP2

Antitoxin

Source ID Structure
AlphaFold DB E2QNP3

References