Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 4026358..4027157 Replicon chromosome
Accession NZ_CP124372
Organism Escherichia coli strain AVS0151

Toxin (Protein)


Gene name yhaV Uniprot ID S1NYM6
Locus tag QJP92_RS20280 Protein ID WP_000347251.1
Coordinates 4026358..4026822 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1PPV5
Locus tag QJP92_RS20285 Protein ID WP_001296435.1
Coordinates 4026822..4027157 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP92_RS20250 (4021359) 4021359..4021793 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
QJP92_RS20255 (4021811) 4021811..4022689 - 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
QJP92_RS20260 (4022679) 4022679..4023458 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
QJP92_RS20265 (4023469) 4023469..4023942 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
QJP92_RS20270 (4023965) 4023965..4025245 - 1281 WP_000681950.1 tagatose-bisphosphate aldolase subunit KbaZ -
QJP92_RS20275 (4025494) 4025494..4026303 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
QJP92_RS20280 (4026358) 4026358..4026822 - 465 WP_000347251.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
QJP92_RS20285 (4026822) 4026822..4027157 - 336 WP_001296435.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
QJP92_RS20290 (4027306) 4027306..4028877 - 1572 WP_001273763.1 galactarate dehydratase -
QJP92_RS20295 (4029252) 4029252..4030586 + 1335 WP_000599651.1 galactarate/glucarate/glycerate transporter GarP -
QJP92_RS20300 (4030602) 4030602..4031372 + 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17777.14 Da        Isoelectric Point: 9.4947

>T279900 WP_000347251.1 NZ_CP124372:c4026822-4026358 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12321.92 Da        Isoelectric Point: 4.5392

>AT279900 WP_001296435.1 NZ_CP124372:c4027157-4026822 [Escherichia coli]
MPANARSNAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CJ20

Antitoxin

Source ID Structure
AlphaFold DB S1PPV5

References