Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 3179196..3179798 Replicon chromosome
Accession NZ_CP124372
Organism Escherichia coli strain AVS0151

Toxin (Protein)


Gene name higB Uniprot ID S1P416
Locus tag QJP92_RS16040 Protein ID WP_000897302.1
Coordinates 3179487..3179798 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QJP92_RS16035 Protein ID WP_000356397.1
Coordinates 3179196..3179486 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP92_RS16005 (3174503) 3174503..3175432 + 930 WP_000027696.1 formate dehydrogenase accessory protein FdhE -
QJP92_RS16010 (3175614) 3175614..3175856 - 243 WP_001068514.1 CopG family transcriptional regulator -
QJP92_RS16015 (3176146) 3176146..3176994 + 849 WP_001038650.1 hypothetical protein -
QJP92_RS16020 (3177019) 3177019..3177759 + 741 WP_000608806.1 hypothetical protein -
QJP92_RS16025 (3177944) 3177944..3178162 - 219 WP_001251293.1 CopG family transcriptional regulator -
QJP92_RS16030 (3178559) 3178559..3178837 - 279 WP_001296612.1 hypothetical protein -
QJP92_RS16035 (3179196) 3179196..3179486 - 291 WP_000356397.1 NadS family protein Antitoxin
QJP92_RS16040 (3179487) 3179487..3179798 - 312 WP_000897302.1 hypothetical protein Toxin
QJP92_RS16045 (3180027) 3180027..3180935 + 909 WP_001385591.1 alpha/beta hydrolase -
QJP92_RS16050 (3180999) 3180999..3181940 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
QJP92_RS16055 (3181985) 3181985..3182422 - 438 WP_000560981.1 D-aminoacyl-tRNA deacylase -
QJP92_RS16060 (3182419) 3182419..3183291 - 873 WP_000920762.1 virulence factor BrkB family protein -
QJP92_RS16065 (3183285) 3183285..3183884 - 600 WP_001296610.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12203.19 Da        Isoelectric Point: 9.7791

>T279898 WP_000897302.1 NZ_CP124372:c3179798-3179487 [Escherichia coli]
MLFIETEIFTEDVQKLLNDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT279898 WP_000356397.1 NZ_CP124372:c3179486-3179196 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P416

Antitoxin

Source ID Structure

References