Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 83819..84321 Replicon chromosome
Accession NZ_CP124372
Organism Escherichia coli strain AVS0151

Toxin (Protein)


Gene name yoeB Uniprot ID E2QNP2
Locus tag QJP92_RS00380 Protein ID WP_000767819.1
Coordinates 84067..84321 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID E2QNP3
Locus tag QJP92_RS00375 Protein ID WP_001259253.1
Coordinates 83819..84070 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP92_RS00350 (78997) 78997..80064 - 1068 WP_000080057.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
QJP92_RS00355 (80064) 80064..81134 - 1071 WP_000108967.1 histidinol-phosphate transaminase -
QJP92_RS00360 (81131) 81131..82435 - 1305 WP_001296211.1 histidinol dehydrogenase -
QJP92_RS00365 (82441) 82441..83340 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
QJP92_RS00370 (83486) 83486..83536 - 51 WP_001364200.1 his operon leader peptide -
QJP92_RS00375 (83819) 83819..84070 + 252 WP_001259253.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
QJP92_RS00380 (84067) 84067..84321 + 255 WP_000767819.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
QJP92_RS00385 (84404) 84404..85228 + 825 WP_000754737.1 SDR family oxidoreductase -
QJP92_RS00390 (85274) 85274..86203 + 930 WP_000803366.1 LysR substrate-binding domain-containing protein -
QJP92_RS00395 (86418) 86418..86480 + 63 WP_010723108.1 membrane protein YoeI -
QJP92_RS00400 (86470) 86470..87828 + 1359 WP_000019194.1 putrescine/proton symporter PlaP -
QJP92_RS00405 (88045) 88045..88503 + 459 WP_001531805.1 IS200/IS605-like element IS200C family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 88045..88503 458


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10110.53 Da        Isoelectric Point: 7.2749

>T279883 WP_000767819.1 NZ_CP124372:84067-84321 [Escherichia coli]
VKLIWSEESWDDYLYWQEADKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHLLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9365.62 Da        Isoelectric Point: 4.6127

>AT279883 WP_001259253.1 NZ_CP124372:83819-84070 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSDKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E2QNP2

Antitoxin

Source ID Structure
AlphaFold DB E2QNP3

References