279871

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HTH_XRE
Location 4252652..4253331 Replicon chromosome
Accession NZ_CP124367
Organism Escherichia coli strain AVS0465

Toxin (Protein)


Gene name higB Uniprot ID S1PK60
Locus tag QJP75_RS20590 Protein ID WP_000057523.1
Coordinates 4252652..4252954 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID S1QAY3
Locus tag QJP75_RS20595 Protein ID WP_000806442.1
Coordinates 4252990..4253331 (+) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP75_RS20565 (4248028) 4248028..4249680 + 1653 WP_000771748.1 bifunctional UDP-sugar hydrolase/5'-nucleotidase -
QJP75_RS20570 (4249718) 4249718..4250221 - 504 WP_000667000.1 hypothetical protein -
QJP75_RS20575 (4250218) 4250218..4251018 - 801 WP_000439798.1 hypothetical protein -
QJP75_RS20580 (4251042) 4251042..4251521 - 480 WP_000186633.1 Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase YbaK -
QJP75_RS20585 (4251725) 4251725..4252519 - 795 WP_000365147.1 TraB/GumN family protein -
QJP75_RS20590 (4252652) 4252652..4252954 + 303 WP_000057523.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QJP75_RS20595 (4252990) 4252990..4253331 + 342 WP_000806442.1 HigA family addiction module antitoxin Antitoxin
QJP75_RS20600 (4253389) 4253389..4255893 - 2505 WP_000083947.1 copper-exporting P-type ATPase CopA -
QJP75_RS20605 (4256155) 4256155..4257087 + 933 WP_000883041.1 glutaminase A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(9-98)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-100)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11809.44 Da        Isoelectric Point: 10.3980

>T279871 WP_000057523.1 NZ_CP124367:4252652-4252954 [Escherichia coli]
MAQKKNIRSFRDAWLADFFVHSTPHRKIPAEIHTTLSRKLDIINAATSHRDLRSPPGNRYEELSGKLQEYSSIRVNKQYR
LIFKWVNGKAEELFLDPHNY

Download         Length: 303 bp

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 13171.10 Da        Isoelectric Point: 5.7790

>AT279871 WP_000806442.1 NZ_CP124367:4252990-4253331 [Escherichia coli]
MKQATRKPTTPGDILLYEYLEPLDLKINELAELLHVHRNSVSALINNNRKLTTEMAFRLAKVFDTTVDFWLNLQAAVDLW
EVENNMRTQEELGRIETVAEYLARREERAKKVA

Download         Length: 342 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PK60

Antitoxin

Source ID Structure
AlphaFold DB S1QAY3

References