279862

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 2997749..2998351 Replicon chromosome
Accession NZ_CP124367
Organism Escherichia coli strain AVS0465

Toxin (Protein)


Gene name higB Uniprot ID S1P416
Locus tag QJP75_RS14595 Protein ID WP_000897302.1
Coordinates 2997749..2998060 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QJP75_RS14600 Protein ID WP_000356397.1
Coordinates 2998061..2998351 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP75_RS14570 (2993663) 2993663..2994262 + 600 WP_001296610.1 glucose-1-phosphatase -
QJP75_RS14575 (2994256) 2994256..2995128 + 873 WP_000920762.1 virulence factor BrkB family protein -
QJP75_RS14580 (2995125) 2995125..2995562 + 438 WP_000560981.1 D-aminoacyl-tRNA deacylase -
QJP75_RS14585 (2995607) 2995607..2996548 + 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
QJP75_RS14590 (2996612) 2996612..2997520 - 909 WP_001385591.1 alpha/beta hydrolase -
QJP75_RS14595 (2997749) 2997749..2998060 + 312 WP_000897302.1 hypothetical protein Toxin
QJP75_RS14600 (2998061) 2998061..2998351 + 291 WP_000356397.1 NadS family protein Antitoxin
QJP75_RS14605 (2998710) 2998710..2998988 + 279 WP_001296612.1 hypothetical protein -
QJP75_RS14610 (2999385) 2999385..2999603 + 219 WP_001251293.1 CopG family transcriptional regulator -
QJP75_RS14615 (2999788) 2999788..3000528 - 741 WP_000608806.1 hypothetical protein -
QJP75_RS14620 (3000553) 3000553..3001401 - 849 WP_001038650.1 hypothetical protein -
QJP75_RS14625 (3001691) 3001691..3001933 + 243 WP_001068514.1 CopG family transcriptional regulator -
QJP75_RS14630 (3002115) 3002115..3003044 - 930 WP_000027696.1 formate dehydrogenase accessory protein FdhE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12203.19 Da        Isoelectric Point: 9.7791

>T279862 WP_000897302.1 NZ_CP124367:2997749-2998060 [Escherichia coli]
MLFIETEIFTEDVQKLLNDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT279862 WP_000356397.1 NZ_CP124367:2998061-2998351 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P416

Antitoxin

Source ID Structure

References