279854

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 829373..829875 Replicon chromosome
Accession NZ_CP124367
Organism Escherichia coli strain AVS0465

Toxin (Protein)


Gene name yoeB Uniprot ID E2QNP2
Locus tag QJP75_RS04360 Protein ID WP_000767819.1
Coordinates 829373..829627 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID E2QNP3
Locus tag QJP75_RS04365 Protein ID WP_001259253.1
Coordinates 829624..829875 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP75_RS04335 (825191) 825191..825649 - 459 WP_001531805.1 IS200/IS605-like element IS200C family transposase -
QJP75_RS04340 (825866) 825866..827224 - 1359 WP_000019194.1 putrescine/proton symporter PlaP -
QJP75_RS04345 (827214) 827214..827276 - 63 WP_010723108.1 membrane protein YoeI -
QJP75_RS04350 (827491) 827491..828420 - 930 WP_000803366.1 LysR substrate-binding domain-containing protein -
QJP75_RS04355 (828466) 828466..829290 - 825 WP_000754737.1 SDR family oxidoreductase -
QJP75_RS04360 (829373) 829373..829627 - 255 WP_000767819.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
QJP75_RS04365 (829624) 829624..829875 - 252 WP_001259253.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
QJP75_RS04370 (830158) 830158..830208 + 51 WP_001364200.1 his operon leader peptide -
QJP75_RS04375 (830354) 830354..831253 + 900 WP_000131782.1 ATP phosphoribosyltransferase -
QJP75_RS04380 (831259) 831259..832563 + 1305 WP_001296211.1 histidinol dehydrogenase -
QJP75_RS04385 (832560) 832560..833630 + 1071 WP_000108967.1 histidinol-phosphate transaminase -
QJP75_RS04390 (833630) 833630..834697 + 1068 WP_000080057.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 825191..825649 458


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10110.53 Da        Isoelectric Point: 7.2749

>T279854 WP_000767819.1 NZ_CP124367:c829627-829373 [Escherichia coli]
VKLIWSEESWDDYLYWQEADKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHLLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9365.62 Da        Isoelectric Point: 4.6127

>AT279854 WP_001259253.1 NZ_CP124367:c829875-829624 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSDKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E2QNP2

Antitoxin

Source ID Structure
AlphaFold DB E2QNP3

References