Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2010636..2011138 Replicon chromosome
Accession NZ_CP124359
Organism Escherichia coli strain AVS0093

Toxin (Protein)


Gene name yoeB Uniprot ID S1P977
Locus tag QJP83_RS09590 Protein ID WP_000767822.1
Coordinates 2010884..2011138 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag QJP83_RS09585 Protein ID WP_001259255.1
Coordinates 2010636..2010887 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP83_RS09560 (2005814) 2005814..2006881 - 1068 WP_000080105.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
QJP83_RS09565 (2006881) 2006881..2007951 - 1071 WP_000108941.1 histidinol-phosphate transaminase -
QJP83_RS09570 (2007948) 2007948..2009252 - 1305 WP_001546022.1 histidinol dehydrogenase -
QJP83_RS09575 (2009258) 2009258..2010157 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
QJP83_RS09580 (2010303) 2010303..2010353 - 51 WP_001364200.1 his operon leader peptide -
QJP83_RS09585 (2010636) 2010636..2010887 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
QJP83_RS09590 (2010884) 2010884..2011138 + 255 WP_000767822.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
QJP83_RS09595 (2011221) 2011221..2012045 + 825 WP_000754737.1 SDR family oxidoreductase -
QJP83_RS09600 (2012091) 2012091..2013020 + 930 WP_000803366.1 LysR substrate-binding domain-containing protein -
QJP83_RS09605 (2013235) 2013235..2013297 + 63 WP_010723108.1 membrane protein YoeI -
QJP83_RS09610 (2013287) 2013287..2014645 + 1359 WP_000019194.1 putrescine/proton symporter PlaP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T279833 WP_000767822.1 NZ_CP124359:2010884-2011138 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINEIIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT279833 WP_001259255.1 NZ_CP124359:2010636-2010887 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P977

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References