Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2000701..2001203 Replicon chromosome
Accession NZ_CP124357
Organism Escherichia coli strain AVS0467

Toxin (Protein)


Gene name yoeB Uniprot ID S1P977
Locus tag QJP58_RS09505 Protein ID WP_000767822.1
Coordinates 2000949..2001203 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag QJP58_RS09500 Protein ID WP_001259255.1
Coordinates 2000701..2000952 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP58_RS09475 (1995879) 1995879..1996946 - 1068 WP_000080105.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
QJP58_RS09480 (1996946) 1996946..1998016 - 1071 WP_000108941.1 histidinol-phosphate transaminase -
QJP58_RS09485 (1998013) 1998013..1999317 - 1305 WP_001546022.1 histidinol dehydrogenase -
QJP58_RS09490 (1999323) 1999323..2000222 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
QJP58_RS09495 (2000368) 2000368..2000418 - 51 WP_001364200.1 his operon leader peptide -
QJP58_RS09500 (2000701) 2000701..2000952 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
QJP58_RS09505 (2000949) 2000949..2001203 + 255 WP_000767822.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
QJP58_RS09510 (2001286) 2001286..2002110 + 825 WP_000754737.1 SDR family oxidoreductase -
QJP58_RS09515 (2002156) 2002156..2003085 + 930 WP_000803366.1 LysR substrate-binding domain-containing protein -
QJP58_RS09520 (2003300) 2003300..2003362 + 63 WP_010723108.1 membrane protein YoeI -
QJP58_RS09525 (2003352) 2003352..2004710 + 1359 WP_000019194.1 putrescine/proton symporter PlaP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T279811 WP_000767822.1 NZ_CP124357:2000949-2001203 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINEIIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT279811 WP_001259255.1 NZ_CP124357:2000701-2000952 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P977

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References