Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 3054299..3054901 Replicon chromosome
Accession NZ_CP124349
Organism Escherichia coli strain AVS0453

Toxin (Protein)


Gene name higB Uniprot ID S1P416
Locus tag QJP64_RS15145 Protein ID WP_000897302.1
Coordinates 3054299..3054610 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QJP64_RS15150 Protein ID WP_000356397.1
Coordinates 3054611..3054901 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP64_RS15120 (3050213) 3050213..3050812 + 600 WP_001296610.1 glucose-1-phosphatase -
QJP64_RS15125 (3050806) 3050806..3051678 + 873 WP_000920762.1 virulence factor BrkB family protein -
QJP64_RS15130 (3051675) 3051675..3052112 + 438 WP_000560981.1 D-aminoacyl-tRNA deacylase -
QJP64_RS15135 (3052157) 3052157..3053098 + 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
QJP64_RS15140 (3053162) 3053162..3054070 - 909 WP_001385591.1 alpha/beta hydrolase -
QJP64_RS15145 (3054299) 3054299..3054610 + 312 WP_000897302.1 hypothetical protein Toxin
QJP64_RS15150 (3054611) 3054611..3054901 + 291 WP_000356397.1 NadS family protein Antitoxin
QJP64_RS15155 (3054986) 3054986..3055198 + 213 WP_000197774.1 hypothetical protein -
QJP64_RS15160 (3055260) 3055260..3055538 + 279 WP_001296612.1 hypothetical protein -
QJP64_RS15165 (3055935) 3055935..3056153 + 219 WP_001251293.1 CopG family transcriptional regulator -
QJP64_RS15170 (3056338) 3056338..3057078 - 741 WP_000608806.1 hypothetical protein -
QJP64_RS15175 (3057103) 3057103..3057951 - 849 WP_001038650.1 hypothetical protein -
QJP64_RS15180 (3058241) 3058241..3058483 + 243 WP_001068514.1 CopG family transcriptional regulator -
QJP64_RS15185 (3058665) 3058665..3059594 - 930 WP_000027696.1 formate dehydrogenase accessory protein FdhE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12203.19 Da        Isoelectric Point: 9.7791

>T279677 WP_000897302.1 NZ_CP124349:3054299-3054610 [Escherichia coli]
MLFIETEIFTEDVQKLLNDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT279677 WP_000356397.1 NZ_CP124349:3054611-3054901 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P416

Antitoxin

Source ID Structure

References