Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 2242072..2242871 Replicon chromosome
Accession NZ_CP124349
Organism Escherichia coli strain AVS0453

Toxin (Protein)


Gene name yhaV Uniprot ID S1NYM6
Locus tag QJP64_RS11170 Protein ID WP_000347251.1
Coordinates 2242407..2242871 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1PPV5
Locus tag QJP64_RS11165 Protein ID WP_001296435.1
Coordinates 2242072..2242407 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP64_RS11150 (2237857) 2237857..2238627 - 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -
QJP64_RS11155 (2238643) 2238643..2239977 - 1335 WP_000599651.1 galactarate/glucarate/glycerate transporter GarP -
QJP64_RS11160 (2240352) 2240352..2241923 + 1572 WP_001273763.1 galactarate dehydratase -
QJP64_RS11165 (2242072) 2242072..2242407 + 336 WP_001296435.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
QJP64_RS11170 (2242407) 2242407..2242871 + 465 WP_000347251.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
QJP64_RS11175 (2242926) 2242926..2243735 - 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
QJP64_RS11180 (2243984) 2243984..2245264 + 1281 WP_000681950.1 tagatose-bisphosphate aldolase subunit KbaZ -
QJP64_RS11185 (2245287) 2245287..2245760 + 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
QJP64_RS11190 (2245771) 2245771..2246550 + 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
QJP64_RS11195 (2246540) 2246540..2247418 + 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
QJP64_RS11200 (2247436) 2247436..2247870 + 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17777.14 Da        Isoelectric Point: 9.4947

>T279675 WP_000347251.1 NZ_CP124349:2242407-2242871 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12321.92 Da        Isoelectric Point: 4.5392

>AT279675 WP_001296435.1 NZ_CP124349:2242072-2242407 [Escherichia coli]
MPANARSNAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CJ20

Antitoxin

Source ID Structure
AlphaFold DB S1PPV5

References