Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 918685..919187 Replicon chromosome
Accession NZ_CP124349
Organism Escherichia coli strain AVS0453

Toxin (Protein)


Gene name yoeB Uniprot ID E2QNP2
Locus tag QJP64_RS04965 Protein ID WP_000767819.1
Coordinates 918685..918939 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID E2QNP3
Locus tag QJP64_RS04970 Protein ID WP_001259253.1
Coordinates 918936..919187 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP64_RS04940 (914503) 914503..914961 - 459 WP_001531805.1 IS200/IS605-like element IS200C family transposase -
QJP64_RS04945 (915178) 915178..916536 - 1359 WP_000019194.1 putrescine/proton symporter PlaP -
QJP64_RS04950 (916526) 916526..916588 - 63 WP_010723108.1 membrane protein YoeI -
QJP64_RS04955 (916803) 916803..917732 - 930 WP_000803366.1 LysR substrate-binding domain-containing protein -
QJP64_RS04960 (917778) 917778..918602 - 825 WP_000754737.1 SDR family oxidoreductase -
QJP64_RS04965 (918685) 918685..918939 - 255 WP_000767819.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
QJP64_RS04970 (918936) 918936..919187 - 252 WP_001259253.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
QJP64_RS04975 (919470) 919470..919520 + 51 WP_001364200.1 his operon leader peptide -
QJP64_RS04980 (919666) 919666..920565 + 900 WP_000131782.1 ATP phosphoribosyltransferase -
QJP64_RS04985 (920571) 920571..921875 + 1305 WP_001296211.1 histidinol dehydrogenase -
QJP64_RS04990 (921872) 921872..922942 + 1071 WP_000108967.1 histidinol-phosphate transaminase -
QJP64_RS04995 (922942) 922942..924009 + 1068 WP_000080057.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 914503..914961 458


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10110.53 Da        Isoelectric Point: 7.2749

>T279671 WP_000767819.1 NZ_CP124349:c918939-918685 [Escherichia coli]
VKLIWSEESWDDYLYWQEADKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHLLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9365.62 Da        Isoelectric Point: 4.6127

>AT279671 WP_001259253.1 NZ_CP124349:c919187-918936 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSDKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E2QNP2

Antitoxin

Source ID Structure
AlphaFold DB E2QNP3

References