Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 605045..605844 Replicon chromosome
Accession NZ_CP124345
Organism Escherichia coli strain AVS0530

Toxin (Protein)


Gene name yhaV Uniprot ID S1NYM6
Locus tag QJP77_RS02985 Protein ID WP_000347251.1
Coordinates 605045..605509 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1PPV5
Locus tag QJP77_RS02990 Protein ID WP_001296435.1
Coordinates 605509..605844 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP77_RS02955 (600046) 600046..600480 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
QJP77_RS02960 (600498) 600498..601376 - 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
QJP77_RS02965 (601366) 601366..602145 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
QJP77_RS02970 (602156) 602156..602629 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
QJP77_RS02975 (602652) 602652..603932 - 1281 WP_000681950.1 tagatose-bisphosphate aldolase subunit KbaZ -
QJP77_RS02980 (604181) 604181..604990 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
QJP77_RS02985 (605045) 605045..605509 - 465 WP_000347251.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
QJP77_RS02990 (605509) 605509..605844 - 336 WP_001296435.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
QJP77_RS02995 (605993) 605993..607564 - 1572 WP_001273763.1 galactarate dehydratase -
QJP77_RS03000 (607939) 607939..609273 + 1335 WP_000599651.1 galactarate/glucarate/glycerate transporter GarP -
QJP77_RS03005 (609289) 609289..610059 + 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17777.14 Da        Isoelectric Point: 9.4947

>T279623 WP_000347251.1 NZ_CP124345:c605509-605045 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12321.92 Da        Isoelectric Point: 4.5392

>AT279623 WP_001296435.1 NZ_CP124345:c605844-605509 [Escherichia coli]
MPANARSNAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CJ20

Antitoxin

Source ID Structure
AlphaFold DB S1PPV5

References