Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 1438051..1438699 Replicon chromosome
Accession NC_018078
Organism Mycobacterium tuberculosis KZN 605

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag TBXG_RS06835 Protein ID WP_003899414.1
Coordinates 1438376..1438699 (+) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag TBXG_RS06830 Protein ID WP_003899415.1
Coordinates 1438051..1438296 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TBXG_RS06790 1433199..1433432 - 234 WP_003413717.1 hypothetical protein -
TBXG_RS06795 1433531..1433803 - 273 WP_003900544.1 hypothetical protein -
TBXG_RS21030 1433709..1434098 + 390 WP_003899422.1 hypothetical protein -
TBXG_RS06800 1434095..1434322 + 228 WP_003899421.1 hypothetical protein -
TBXG_RS06805 1434467..1435594 + 1128 WP_003899420.1 site-specific integrase -
TBXG_RS06810 1435597..1435959 + 363 WP_003900543.1 hypothetical protein -
TBXG_RS06815 1435976..1436236 + 261 WP_003899418.1 helix-turn-helix domain-containing protein -
TBXG_RS06820 1436233..1436625 + 393 WP_003899417.1 DUF2742 domain-containing protein -
TBXG_RS06825 1436627..1438054 + 1428 WP_003899416.1 DUF3631 domain-containing protein -
TBXG_RS06830 1438051..1438296 + 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
TBXG_RS06835 1438376..1438699 + 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
TBXG_RS21035 1438866..1439357 + 492 WP_003900541.1 phage terminase small subunit P27 family -
TBXG_RS06845 1439510..1440043 + 534 WP_003899412.1 HK97 family phage prohead protease -
TBXG_RS06850 1440051..1441490 + 1440 WP_003899411.1 phage major capsid protein -
TBXG_RS06855 1441661..1441912 - 252 WP_003908028.1 hypothetical protein -
TBXG_RS06860 1441900..1442364 - 465 WP_003900539.1 ParB N-terminal domain-containing protein -
TBXG_RS06865 1442378..1443376 - 999 WP_003900538.1 tyrosine-type recombinase/integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1434467..1443376 8909


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T27962 WP_003899414.1 NC_018078:1438376-1438699 [Mycobacterium tuberculosis KZN 605]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T27962 NC_018078:1438376-1438699 [Mycobacterium tuberculosis KZN 605]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT27962 WP_003899415.1 NC_018078:1438051-1438296 [Mycobacterium tuberculosis KZN 605]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT27962 NC_018078:1438051-1438296 [Mycobacterium tuberculosis KZN 605]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References