Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2012163..2012665 Replicon chromosome
Accession NZ_CP124339
Organism Escherichia coli strain AVS0713

Toxin (Protein)


Gene name yoeB Uniprot ID S1P977
Locus tag QJP93_RS09590 Protein ID WP_000767822.1
Coordinates 2012411..2012665 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag QJP93_RS09585 Protein ID WP_001259255.1
Coordinates 2012163..2012414 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP93_RS09560 (2007341) 2007341..2008408 - 1068 WP_000080105.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
QJP93_RS09565 (2008408) 2008408..2009478 - 1071 WP_000108941.1 histidinol-phosphate transaminase -
QJP93_RS09570 (2009475) 2009475..2010779 - 1305 WP_001546022.1 histidinol dehydrogenase -
QJP93_RS09575 (2010785) 2010785..2011684 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
QJP93_RS09580 (2011830) 2011830..2011880 - 51 WP_001364200.1 his operon leader peptide -
QJP93_RS09585 (2012163) 2012163..2012414 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
QJP93_RS09590 (2012411) 2012411..2012665 + 255 WP_000767822.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
QJP93_RS09595 (2012748) 2012748..2013572 + 825 WP_000754737.1 SDR family oxidoreductase -
QJP93_RS09600 (2013618) 2013618..2014547 + 930 WP_000803366.1 LysR substrate-binding domain-containing protein -
QJP93_RS09605 (2014762) 2014762..2014824 + 63 WP_010723108.1 membrane protein YoeI -
QJP93_RS09610 (2014814) 2014814..2016172 + 1359 WP_000019194.1 putrescine/proton symporter PlaP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T279561 WP_000767822.1 NZ_CP124339:2012411-2012665 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINEIIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT279561 WP_001259255.1 NZ_CP124339:2012163-2012414 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P977

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References