Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 4956981..4957483 Replicon chromosome
Accession NZ_CP124334
Organism Escherichia coli strain AVS0786

Toxin (Protein)


Gene name yoeB Uniprot ID S1P977
Locus tag QJP89_RS23975 Protein ID WP_000767822.1
Coordinates 4957229..4957483 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag QJP89_RS23970 Protein ID WP_001259255.1
Coordinates 4956981..4957232 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP89_RS23945 (4952159) 4952159..4953226 - 1068 WP_000080105.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
QJP89_RS23950 (4953226) 4953226..4954296 - 1071 WP_000108941.1 histidinol-phosphate transaminase -
QJP89_RS23955 (4954293) 4954293..4955597 - 1305 WP_001546022.1 histidinol dehydrogenase -
QJP89_RS23960 (4955603) 4955603..4956502 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
QJP89_RS23965 (4956648) 4956648..4956698 - 51 WP_001364200.1 his operon leader peptide -
QJP89_RS23970 (4956981) 4956981..4957232 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
QJP89_RS23975 (4957229) 4957229..4957483 + 255 WP_000767822.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
QJP89_RS23980 (4957566) 4957566..4958390 + 825 WP_000754737.1 SDR family oxidoreductase -
QJP89_RS23985 (4958436) 4958436..4959365 + 930 WP_000803366.1 LysR substrate-binding domain-containing protein -
QJP89_RS23990 (4959580) 4959580..4959642 + 63 WP_010723108.1 membrane protein YoeI -
QJP89_RS23995 (4959632) 4959632..4960990 + 1359 WP_000019194.1 putrescine/proton symporter PlaP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T279531 WP_000767822.1 NZ_CP124334:4957229-4957483 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINEIIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT279531 WP_001259255.1 NZ_CP124334:4956981-4957232 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P977

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References