Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 3142813..3144131 Replicon chromosome
Accession NZ_CP124334
Organism Escherichia coli strain AVS0786

Toxin (Protein)


Gene name HipT Uniprot ID F4T5A3
Locus tag QJP89_RS15355 Protein ID WP_001262467.1
Coordinates 3143124..3144131 (+) Length 336 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID F4T5A4
Locus tag QJP89_RS15350 Protein ID WP_001312177.1
Coordinates 3142813..3143124 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP89_RS15325 (3138345) 3138345..3139364 + 1020 WP_000938855.1 dipeptide ABC transporter permease DppB -
QJP89_RS15330 (3139374) 3139374..3140276 + 903 WP_000084677.1 dipeptide ABC transporter permease DppC -
QJP89_RS15335 (3140287) 3140287..3141270 + 984 WP_001196477.1 dipeptide ABC transporter ATP-binding protein -
QJP89_RS15340 (3141267) 3141267..3142280 + 1014 WP_000103572.1 dipeptide ABC transporter ATP-binding subunit DppF -
QJP89_RS15345 (3142505) 3142505..3142828 + 324 WP_000563102.1 helix-turn-helix transcriptional regulator -
QJP89_RS15350 (3142813) 3142813..3143124 + 312 WP_001312177.1 HipA N-terminal domain-containing protein Antitoxin
QJP89_RS15355 (3143124) 3143124..3144131 + 1008 WP_001262467.1 HipA domain-containing protein Toxin
QJP89_RS15360 (3144148) 3144148..3145419 - 1272 WP_001545666.1 amino acid permease -
- (3145781) 3145781..3145846 - 66 NuclAT_27 - -
- (3145781) 3145781..3145846 - 66 NuclAT_27 - -
- (3145781) 3145781..3145846 - 66 NuclAT_27 - -
- (3145781) 3145781..3145846 - 66 NuclAT_27 - -
QJP89_RS15365 (3145895) 3145895..3146002 + 108 WP_001295224.1 type I toxin-antitoxin system toxin Ldr family protein -
- (3146264) 3146264..3146321 - 58 NuclAT_26 - -
- (3146264) 3146264..3146321 - 58 NuclAT_26 - -
- (3146264) 3146264..3146321 - 58 NuclAT_26 - -
- (3146264) 3146264..3146321 - 58 NuclAT_26 - -
QJP89_RS15370 (3146378) 3146378..3146485 + 108 WP_000170748.1 type I toxin-antitoxin system toxin Ldr family protein -
QJP89_RS15375 (3146861) 3146861..3146968 + 108 WP_001295224.1 type I toxin-antitoxin system toxin Ldr family protein -
QJP89_RS15380 (3147054) 3147054..3148733 - 1680 Protein_3006 cellulose biosynthesis protein BcsG -
QJP89_RS15385 (3148730) 3148730..3148921 - 192 WP_000988308.1 cellulose biosynthesis protein BcsF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(56-302)

Antitoxin

HipA, N-terminal subdomain 1

(6-98)


Sequences

Toxin        


Download         Length: 336 a.a.        Molecular weight: 38320.60 Da        Isoelectric Point: 5.5965

>T279525 WP_001262467.1 NZ_CP124334:3143124-3144131 [Escherichia coli]
MANCRILLTPLNERDEQRGYSTQGLKRLSGTAKLTPRLGFTRTQFVQELPRQQKGMSISGYQPKLQLVLDEGEFRVVDHQ
GNFILKPSPADFPGLAENEHATMTLMSRLGFDVPVHGLLSFAPQSEEELEYAFVIRRYDRDNKGLPVHQEQLDGAMQIMD
KYGKTGNDNEQYVSYETLARFLVAHVNDNIAFKIDLFRRIVYAWLLGNNDMHLRNFGLVYSDGLTPALAPVYDFVSVAPY
PEYFHSNYLALPLLTREEGGRELAPGFHSDYGEYIGQDFLLLGESMGLAPRLLEKLFQDIRKENAIVMETYEQSFMTQDH
IQAVLQCYRHRLGLL

Download         Length: 1008 bp

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11821.47 Da        Isoelectric Point: 6.0609

>AT279525 WP_001312177.1 NZ_CP124334:3142813-3143124 [Escherichia coli]
MHRRVKVLLYGQVVGELSQNDSGFLFQYAPDYHGPAISISLPVAQRQFPSEMLHPYFASLAPEGWLRQRYSQIQHRDEND
LLGMLIDNGKNLLGAIQILPWEE

Download         Length: 312 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3K2ZTB5

Antitoxin

Source ID Structure
AlphaFold DB A0A3L3HKE2

References