Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 3054657..3055259 Replicon chromosome
Accession NZ_CP124332
Organism Escherichia coli strain AVS0753

Toxin (Protein)


Gene name higB Uniprot ID S1P416
Locus tag QJP82_RS15165 Protein ID WP_000897302.1
Coordinates 3054657..3054968 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QJP82_RS15170 Protein ID WP_000356397.1
Coordinates 3054969..3055259 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP82_RS15140 (3050571) 3050571..3051170 + 600 WP_001296610.1 glucose-1-phosphatase -
QJP82_RS15145 (3051164) 3051164..3052036 + 873 WP_000920762.1 virulence factor BrkB family protein -
QJP82_RS15150 (3052033) 3052033..3052470 + 438 WP_000560981.1 D-aminoacyl-tRNA deacylase -
QJP82_RS15155 (3052515) 3052515..3053456 + 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
QJP82_RS15160 (3053520) 3053520..3054428 - 909 WP_001385591.1 alpha/beta hydrolase -
QJP82_RS15165 (3054657) 3054657..3054968 + 312 WP_000897302.1 hypothetical protein Toxin
QJP82_RS15170 (3054969) 3054969..3055259 + 291 WP_000356397.1 NadS family protein Antitoxin
QJP82_RS15175 (3055344) 3055344..3055556 + 213 WP_000197774.1 hypothetical protein -
QJP82_RS15180 (3055618) 3055618..3055896 + 279 WP_001296612.1 hypothetical protein -
QJP82_RS15185 (3056293) 3056293..3056511 + 219 WP_001251293.1 CopG family transcriptional regulator -
QJP82_RS15190 (3056696) 3056696..3057436 - 741 WP_000608806.1 hypothetical protein -
QJP82_RS15195 (3057461) 3057461..3058309 - 849 WP_001038650.1 hypothetical protein -
QJP82_RS15200 (3058599) 3058599..3058841 + 243 WP_001068514.1 CopG family transcriptional regulator -
QJP82_RS15205 (3059023) 3059023..3059952 - 930 WP_000027696.1 formate dehydrogenase accessory protein FdhE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12203.19 Da        Isoelectric Point: 9.7791

>T279489 WP_000897302.1 NZ_CP124332:3054657-3054968 [Escherichia coli]
MLFIETEIFTEDVQKLLNDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT279489 WP_000356397.1 NZ_CP124332:3054969-3055259 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P416

Antitoxin

Source ID Structure

References