Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 2242430..2243229 Replicon chromosome
Accession NZ_CP124332
Organism Escherichia coli strain AVS0753

Toxin (Protein)


Gene name yhaV Uniprot ID S1NYM6
Locus tag QJP82_RS11190 Protein ID WP_000347251.1
Coordinates 2242765..2243229 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1PPV5
Locus tag QJP82_RS11185 Protein ID WP_001296435.1
Coordinates 2242430..2242765 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP82_RS11170 (2238215) 2238215..2238985 - 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -
QJP82_RS11175 (2239001) 2239001..2240335 - 1335 WP_000599651.1 galactarate/glucarate/glycerate transporter GarP -
QJP82_RS11180 (2240710) 2240710..2242281 + 1572 WP_001273763.1 galactarate dehydratase -
QJP82_RS11185 (2242430) 2242430..2242765 + 336 WP_001296435.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
QJP82_RS11190 (2242765) 2242765..2243229 + 465 WP_000347251.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
QJP82_RS11195 (2243284) 2243284..2244093 - 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
QJP82_RS11200 (2244342) 2244342..2245622 + 1281 WP_000681950.1 tagatose-bisphosphate aldolase subunit KbaZ -
QJP82_RS11205 (2245645) 2245645..2246118 + 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
QJP82_RS11210 (2246129) 2246129..2246908 + 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
QJP82_RS11215 (2246898) 2246898..2247776 + 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
QJP82_RS11220 (2247794) 2247794..2248228 + 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17777.14 Da        Isoelectric Point: 9.4947

>T279487 WP_000347251.1 NZ_CP124332:2242765-2243229 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12321.92 Da        Isoelectric Point: 4.5392

>AT279487 WP_001296435.1 NZ_CP124332:2242430-2242765 [Escherichia coli]
MPANARSNAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CJ20

Antitoxin

Source ID Structure
AlphaFold DB S1PPV5

References