Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3870482..3871209 Replicon chromosome
Accession NZ_CP124328
Organism Escherichia coli strain AVS0787

Toxin (Protein)


Gene name higB Uniprot ID U9ZMR4
Locus tag QJP62_RS19285 Protein ID WP_000550189.1
Coordinates 3870482..3870796 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QJP62_RS19290 Protein ID WP_000560269.1
Coordinates 3870793..3871209 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP62_RS19265 (3866639) 3866639..3867625 - 987 WP_001385498.1 Gfo/Idh/MocA family oxidoreductase -
QJP62_RS19270 (3867704) 3867704..3868396 - 693 WP_000942551.1 vancomycin high temperature exclusion protein -
QJP62_RS19275 (3868473) 3868473..3868976 - 504 WP_001295542.1 M48 family metallopeptidase -
QJP62_RS19280 (3869061) 3869061..3870197 + 1137 WP_000018703.1 23S rRNA (guanine(1835)-N(2))-methyltransferase RlmG -
QJP62_RS19285 (3870482) 3870482..3870796 + 315 WP_000550189.1 type II toxin-antitoxin system toxin HigB Toxin
QJP62_RS19290 (3870793) 3870793..3871209 + 417 WP_000560269.1 type II toxin-antitoxin system antitoxin HigA Antitoxin
QJP62_RS19295 (3871254) 3871254..3873272 - 2019 WP_000121413.1 NADPH-dependent 2,4-dienoyl-CoA reductase -
QJP62_RS19300 (3873498) 3873498..3875849 - 2352 WP_000695432.1 alpha-glucosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(84-135)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 12103.10 Da        Isoelectric Point: 10.0409

>T279456 WP_000550189.1 NZ_CP124328:3870482-3870796 [Escherichia coli]
MHLITQKALKDAAEKYPQHKTELVALGNTIAKGYFKKPESLKAVFPSLDNFKYLDKHYVFNVGGNELRVVAMVFFESQKC
YIREVMTHKEYDFFTAVHRTKGKK

Download         Length: 315 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15023.47 Da        Isoelectric Point: 4.4547

>AT279456 WP_000560269.1 NZ_CP124328:3870793-3871209 [Escherichia coli]
MIAIADILQAGEKLTAVAPFLAGIQNEEQYTQALELVDHLLLNDPENPLLDLVCAKITAWEESAPEFVEFNAMAQAMPGG
IAVIRTLMDQYGLTLSDLPEIGSKSMVSRVLSGKRKLTLEHAKKLATRFGISPALFID

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6KMQ
PDB 5IFG
PDB 5YCL
PDB 6KML

Antitoxin

Source ID Structure

References