Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 3828702..3829501 Replicon chromosome
Accession NZ_CP124328
Organism Escherichia coli strain AVS0787

Toxin (Protein)


Gene name yhaV Uniprot ID S1NYM6
Locus tag QJP62_RS19055 Protein ID WP_000347251.1
Coordinates 3828702..3829166 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1PPV5
Locus tag QJP62_RS19060 Protein ID WP_001296435.1
Coordinates 3829166..3829501 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP62_RS19025 (3823703) 3823703..3824137 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
QJP62_RS19030 (3824155) 3824155..3825033 - 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
QJP62_RS19035 (3825023) 3825023..3825802 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
QJP62_RS19040 (3825813) 3825813..3826286 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
QJP62_RS19045 (3826309) 3826309..3827589 - 1281 WP_000681950.1 tagatose-bisphosphate aldolase subunit KbaZ -
QJP62_RS19050 (3827838) 3827838..3828647 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
QJP62_RS19055 (3828702) 3828702..3829166 - 465 WP_000347251.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
QJP62_RS19060 (3829166) 3829166..3829501 - 336 WP_001296435.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
QJP62_RS19065 (3829650) 3829650..3831221 - 1572 WP_001273763.1 galactarate dehydratase -
QJP62_RS19070 (3831596) 3831596..3832930 + 1335 WP_000599651.1 galactarate/glucarate/glycerate transporter GarP -
QJP62_RS19075 (3832946) 3832946..3833716 + 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17777.14 Da        Isoelectric Point: 9.4947

>T279455 WP_000347251.1 NZ_CP124328:c3829166-3828702 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12321.92 Da        Isoelectric Point: 4.5392

>AT279455 WP_001296435.1 NZ_CP124328:c3829501-3829166 [Escherichia coli]
MPANARSNAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CJ20

Antitoxin

Source ID Structure
AlphaFold DB S1PPV5

References