Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 3016670..3017272 Replicon chromosome
Accession NZ_CP124328
Organism Escherichia coli strain AVS0787

Toxin (Protein)


Gene name higB Uniprot ID S1P416
Locus tag QJP62_RS15080 Protein ID WP_000897302.1
Coordinates 3016961..3017272 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QJP62_RS15075 Protein ID WP_000356397.1
Coordinates 3016670..3016960 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP62_RS15040 (3011977) 3011977..3012906 + 930 WP_000027696.1 formate dehydrogenase accessory protein FdhE -
QJP62_RS15045 (3013088) 3013088..3013330 - 243 WP_001068514.1 CopG family transcriptional regulator -
QJP62_RS15050 (3013620) 3013620..3014468 + 849 WP_001038650.1 hypothetical protein -
QJP62_RS15055 (3014493) 3014493..3015233 + 741 WP_000608806.1 hypothetical protein -
QJP62_RS15060 (3015418) 3015418..3015636 - 219 WP_001251293.1 CopG family transcriptional regulator -
QJP62_RS15065 (3016033) 3016033..3016311 - 279 WP_001296612.1 hypothetical protein -
QJP62_RS15070 (3016373) 3016373..3016585 - 213 WP_000197774.1 hypothetical protein -
QJP62_RS15075 (3016670) 3016670..3016960 - 291 WP_000356397.1 NadS family protein Antitoxin
QJP62_RS15080 (3016961) 3016961..3017272 - 312 WP_000897302.1 hypothetical protein Toxin
QJP62_RS15085 (3017501) 3017501..3018409 + 909 WP_001385591.1 alpha/beta hydrolase -
QJP62_RS15090 (3018473) 3018473..3019414 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
QJP62_RS15095 (3019459) 3019459..3019896 - 438 WP_000560981.1 D-aminoacyl-tRNA deacylase -
QJP62_RS15100 (3019893) 3019893..3020765 - 873 WP_000920762.1 virulence factor BrkB family protein -
QJP62_RS15105 (3020759) 3020759..3021358 - 600 WP_001296610.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12203.19 Da        Isoelectric Point: 9.7791

>T279453 WP_000897302.1 NZ_CP124328:c3017272-3016961 [Escherichia coli]
MLFIETEIFTEDVQKLLNDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT279453 WP_000356397.1 NZ_CP124328:c3016960-3016670 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P416

Antitoxin

Source ID Structure

References