Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HTH_XRE
Location 1710417..1711096 Replicon chromosome
Accession NZ_CP124328
Organism Escherichia coli strain AVS0787

Toxin (Protein)


Gene name higB Uniprot ID S1PK60
Locus tag QJP62_RS08890 Protein ID WP_000057523.1
Coordinates 1710794..1711096 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID S1QAY3
Locus tag QJP62_RS08885 Protein ID WP_000806442.1
Coordinates 1710417..1710758 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP62_RS08875 (1706661) 1706661..1707593 - 933 WP_000883041.1 glutaminase A -
QJP62_RS08880 (1707855) 1707855..1710359 + 2505 WP_000083947.1 copper-exporting P-type ATPase CopA -
QJP62_RS08885 (1710417) 1710417..1710758 - 342 WP_000806442.1 HigA family addiction module antitoxin Antitoxin
QJP62_RS08890 (1710794) 1710794..1711096 - 303 WP_000057523.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QJP62_RS08895 (1711229) 1711229..1712023 + 795 WP_000365147.1 TraB/GumN family protein -
QJP62_RS08900 (1712227) 1712227..1712706 + 480 WP_000186633.1 Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase YbaK -
QJP62_RS08905 (1712874) 1712874..1713530 + 657 WP_015674862.1 hypothetical protein -
QJP62_RS08910 (1713527) 1713527..1714030 + 504 WP_000667000.1 hypothetical protein -
QJP62_RS08915 (1714068) 1714068..1715720 - 1653 WP_000771748.1 bifunctional UDP-sugar hydrolase/5'-nucleotidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(9-98)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-100)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11809.44 Da        Isoelectric Point: 10.3980

>T279444 WP_000057523.1 NZ_CP124328:c1711096-1710794 [Escherichia coli]
MAQKKNIRSFRDAWLADFFVHSTPHRKIPAEIHTTLSRKLDIINAATSHRDLRSPPGNRYEELSGKLQEYSSIRVNKQYR
LIFKWVNGKAEELFLDPHNY

Download         Length: 303 bp

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 13171.10 Da        Isoelectric Point: 5.7790

>AT279444 WP_000806442.1 NZ_CP124328:c1710758-1710417 [Escherichia coli]
MKQATRKPTTPGDILLYEYLEPLDLKINELAELLHVHRNSVSALINNNRKLTTEMAFRLAKVFDTTVDFWLNLQAAVDLW
EVENNMRTQEELGRIETVAEYLARREERAKKVA

Download         Length: 342 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PK60

Antitoxin

Source ID Structure
PDB 2EBY
AlphaFold DB S1QAY3

References