Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2010628..2011130 Replicon chromosome
Accession NZ_CP124326
Organism Escherichia coli strain AVS0285

Toxin (Protein)


Gene name yoeB Uniprot ID S1P977
Locus tag QJP69_RS09590 Protein ID WP_000767822.1
Coordinates 2010876..2011130 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag QJP69_RS09585 Protein ID WP_001259255.1
Coordinates 2010628..2010879 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP69_RS09560 (2005806) 2005806..2006873 - 1068 WP_000080105.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
QJP69_RS09565 (2006873) 2006873..2007943 - 1071 WP_000108941.1 histidinol-phosphate transaminase -
QJP69_RS09570 (2007940) 2007940..2009244 - 1305 WP_001546022.1 histidinol dehydrogenase -
QJP69_RS09575 (2009250) 2009250..2010149 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
QJP69_RS09580 (2010295) 2010295..2010345 - 51 WP_001364200.1 his operon leader peptide -
QJP69_RS09585 (2010628) 2010628..2010879 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
QJP69_RS09590 (2010876) 2010876..2011130 + 255 WP_000767822.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
QJP69_RS09595 (2011213) 2011213..2012037 + 825 WP_000754737.1 SDR family oxidoreductase -
QJP69_RS09600 (2012083) 2012083..2013012 + 930 WP_000803366.1 LysR substrate-binding domain-containing protein -
QJP69_RS09605 (2013227) 2013227..2013289 + 63 WP_010723108.1 membrane protein YoeI -
QJP69_RS09610 (2013279) 2013279..2014637 + 1359 WP_000019194.1 putrescine/proton symporter PlaP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T279421 WP_000767822.1 NZ_CP124326:2010876-2011130 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINEIIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT279421 WP_001259255.1 NZ_CP124326:2010628-2010879 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P977

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References