Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2012016..2012518 Replicon chromosome
Accession NZ_CP124324
Organism Escherichia coli strain AVS0536

Toxin (Protein)


Gene name yoeB Uniprot ID S1P977
Locus tag QJP54_RS09585 Protein ID WP_000767822.1
Coordinates 2012264..2012518 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag QJP54_RS09580 Protein ID WP_001259255.1
Coordinates 2012016..2012267 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP54_RS09555 (2007194) 2007194..2008261 - 1068 WP_000080105.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
QJP54_RS09560 (2008261) 2008261..2009331 - 1071 WP_000108941.1 histidinol-phosphate transaminase -
QJP54_RS09565 (2009328) 2009328..2010632 - 1305 WP_001546022.1 histidinol dehydrogenase -
QJP54_RS09570 (2010638) 2010638..2011537 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
QJP54_RS09575 (2011683) 2011683..2011733 - 51 WP_001364200.1 his operon leader peptide -
QJP54_RS09580 (2012016) 2012016..2012267 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
QJP54_RS09585 (2012264) 2012264..2012518 + 255 WP_000767822.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
QJP54_RS09590 (2012601) 2012601..2013425 + 825 WP_000754737.1 SDR family oxidoreductase -
QJP54_RS09595 (2013471) 2013471..2014400 + 930 WP_000803366.1 LysR substrate-binding domain-containing protein -
QJP54_RS09600 (2014615) 2014615..2014677 + 63 WP_010723108.1 membrane protein YoeI -
QJP54_RS09605 (2014667) 2014667..2016025 + 1359 WP_000019194.1 putrescine/proton symporter PlaP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T279399 WP_000767822.1 NZ_CP124324:2012264-2012518 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINEIIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT279399 WP_001259255.1 NZ_CP124324:2012016-2012267 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P977

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References