Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 4471924..4472723 Replicon chromosome
Accession NZ_CP124320
Organism Escherichia coli strain AVS0754

Toxin (Protein)


Gene name yhaV Uniprot ID S1NYM6
Locus tag QJP81_RS21765 Protein ID WP_000347251.1
Coordinates 4472259..4472723 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1PPV5
Locus tag QJP81_RS21760 Protein ID WP_001296435.1
Coordinates 4471924..4472259 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP81_RS21745 (4467709) 4467709..4468479 - 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -
QJP81_RS21750 (4468495) 4468495..4469829 - 1335 WP_000599651.1 galactarate/glucarate/glycerate transporter GarP -
QJP81_RS21755 (4470204) 4470204..4471775 + 1572 WP_001273763.1 galactarate dehydratase -
QJP81_RS21760 (4471924) 4471924..4472259 + 336 WP_001296435.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
QJP81_RS21765 (4472259) 4472259..4472723 + 465 WP_000347251.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
QJP81_RS21770 (4472778) 4472778..4473587 - 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
QJP81_RS21775 (4473836) 4473836..4475116 + 1281 WP_000681950.1 tagatose-bisphosphate aldolase subunit KbaZ -
QJP81_RS21780 (4475139) 4475139..4475612 + 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
QJP81_RS21785 (4475623) 4475623..4476402 + 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
QJP81_RS21790 (4476392) 4476392..4477270 + 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
QJP81_RS21795 (4477288) 4477288..4477722 + 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17777.14 Da        Isoelectric Point: 9.4947

>T279370 WP_000347251.1 NZ_CP124320:4472259-4472723 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12321.92 Da        Isoelectric Point: 4.5392

>AT279370 WP_001296435.1 NZ_CP124320:4471924-4472259 [Escherichia coli]
MPANARSNAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CJ20

Antitoxin

Source ID Structure
AlphaFold DB S1PPV5

References