Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4431469..4432196 Replicon chromosome
Accession NZ_CP124320
Organism Escherichia coli strain AVS0754

Toxin (Protein)


Gene name higB Uniprot ID U9ZMR4
Locus tag QJP81_RS21545 Protein ID WP_000550189.1
Coordinates 4431882..4432196 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QJP81_RS21540 Protein ID WP_000560269.1
Coordinates 4431469..4431885 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP81_RS21530 (4426829) 4426829..4429180 + 2352 WP_000695431.1 alpha-glucosidase -
QJP81_RS21535 (4429406) 4429406..4431424 + 2019 WP_000121413.1 NADPH-dependent 2,4-dienoyl-CoA reductase -
QJP81_RS21540 (4431469) 4431469..4431885 - 417 WP_000560269.1 type II toxin-antitoxin system antitoxin HigA Antitoxin
QJP81_RS21545 (4431882) 4431882..4432196 - 315 WP_000550189.1 type II toxin-antitoxin system toxin HigB Toxin
QJP81_RS21550 (4432481) 4432481..4433617 - 1137 WP_000018703.1 23S rRNA (guanine(1835)-N(2))-methyltransferase RlmG -
QJP81_RS21555 (4433702) 4433702..4434205 + 504 WP_001295542.1 M48 family metallopeptidase -
QJP81_RS21560 (4434282) 4434282..4434974 + 693 WP_000942551.1 vancomycin high temperature exclusion protein -
QJP81_RS21565 (4435053) 4435053..4436039 + 987 WP_001385498.1 Gfo/Idh/MocA family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(84-135)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 12103.10 Da        Isoelectric Point: 10.0409

>T279369 WP_000550189.1 NZ_CP124320:c4432196-4431882 [Escherichia coli]
MHLITQKALKDAAEKYPQHKTELVALGNTIAKGYFKKPESLKAVFPSLDNFKYLDKHYVFNVGGNELRVVAMVFFESQKC
YIREVMTHKEYDFFTAVHRTKGKK

Download         Length: 315 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15023.47 Da        Isoelectric Point: 4.4547

>AT279369 WP_000560269.1 NZ_CP124320:c4431885-4431469 [Escherichia coli]
MIAIADILQAGEKLTAVAPFLAGIQNEEQYTQALELVDHLLLNDPENPLLDLVCAKITAWEESAPEFVEFNAMAQAMPGG
IAVIRTLMDQYGLTLSDLPEIGSKSMVSRVLSGKRKLTLEHAKKLATRFGISPALFID

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6KMQ
PDB 5IFG
PDB 5YCL
PDB 6KML

Antitoxin

Source ID Structure

References