Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 3213644..3214146 Replicon chromosome
Accession NZ_CP124320
Organism Escherichia coli strain AVS0754

Toxin (Protein)


Gene name yoeB Uniprot ID S1P977
Locus tag QJP81_RS15960 Protein ID WP_000767822.1
Coordinates 3213644..3213898 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag QJP81_RS15965 Protein ID WP_001259255.1
Coordinates 3213895..3214146 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP81_RS15940 (3210137) 3210137..3211495 - 1359 WP_000019194.1 putrescine/proton symporter PlaP -
QJP81_RS15945 (3211485) 3211485..3211547 - 63 WP_010723108.1 membrane protein YoeI -
QJP81_RS15950 (3211762) 3211762..3212691 - 930 WP_000803366.1 LysR substrate-binding domain-containing protein -
QJP81_RS15955 (3212737) 3212737..3213561 - 825 WP_000754737.1 SDR family oxidoreductase -
QJP81_RS15960 (3213644) 3213644..3213898 - 255 WP_000767822.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
QJP81_RS15965 (3213895) 3213895..3214146 - 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
QJP81_RS15970 (3214429) 3214429..3214479 + 51 WP_001364200.1 his operon leader peptide -
QJP81_RS15975 (3214625) 3214625..3215524 + 900 WP_000131782.1 ATP phosphoribosyltransferase -
QJP81_RS15980 (3215530) 3215530..3216834 + 1305 WP_001546022.1 histidinol dehydrogenase -
QJP81_RS15985 (3216831) 3216831..3217901 + 1071 WP_000108941.1 histidinol-phosphate transaminase -
QJP81_RS15990 (3217901) 3217901..3218968 + 1068 WP_000080105.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T279366 WP_000767822.1 NZ_CP124320:c3213898-3213644 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINEIIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT279366 WP_001259255.1 NZ_CP124320:c3214146-3213895 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P977

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References