279347

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 253030..254348 Replicon chromosome
Accession NZ_CP124320
Organism Escherichia coli strain AVS0754

Toxin (Protein)


Gene name HipT Uniprot ID F4T5A3
Locus tag QJP81_RS01190 Protein ID WP_001262467.1
Coordinates 253341..254348 (+) Length 336 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID F4T5A4
Locus tag QJP81_RS01185 Protein ID WP_001312177.1
Coordinates 253030..253341 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP81_RS01160 (248562) 248562..249581 + 1020 WP_000938855.1 dipeptide ABC transporter permease DppB -
QJP81_RS01165 (249591) 249591..250493 + 903 WP_000084677.1 dipeptide ABC transporter permease DppC -
QJP81_RS01170 (250504) 250504..251487 + 984 WP_001196477.1 dipeptide ABC transporter ATP-binding protein -
QJP81_RS01175 (251484) 251484..252497 + 1014 WP_000103572.1 dipeptide ABC transporter ATP-binding subunit DppF -
QJP81_RS01180 (252722) 252722..253045 + 324 WP_000563102.1 helix-turn-helix transcriptional regulator -
QJP81_RS01185 (253030) 253030..253341 + 312 WP_001312177.1 HipA N-terminal domain-containing protein Antitoxin
QJP81_RS01190 (253341) 253341..254348 + 1008 WP_001262467.1 HipA domain-containing protein Toxin
QJP81_RS01195 (254365) 254365..255636 - 1272 WP_001545666.1 amino acid permease -
- (255998) 255998..256063 - 66 NuclAT_27 - -
- (255998) 255998..256063 - 66 NuclAT_27 - -
- (255998) 255998..256063 - 66 NuclAT_27 - -
- (255998) 255998..256063 - 66 NuclAT_27 - -
QJP81_RS01200 (256112) 256112..256219 + 108 WP_001295224.1 type I toxin-antitoxin system toxin Ldr family protein -
- (256481) 256481..256538 - 58 NuclAT_26 - -
- (256481) 256481..256538 - 58 NuclAT_26 - -
- (256481) 256481..256538 - 58 NuclAT_26 - -
- (256481) 256481..256538 - 58 NuclAT_26 - -
QJP81_RS01205 (256595) 256595..256702 + 108 WP_000170748.1 type I toxin-antitoxin system toxin Ldr family protein -
QJP81_RS01210 (257078) 257078..257185 + 108 WP_001295224.1 type I toxin-antitoxin system toxin Ldr family protein -
QJP81_RS01215 (257271) 257271..258950 - 1680 Protein_240 cellulose biosynthesis protein BcsG -
QJP81_RS01220 (258947) 258947..259138 - 192 WP_000988308.1 cellulose biosynthesis protein BcsF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(56-302)

Antitoxin

HipA, N-terminal subdomain 1

(6-98)


Sequences

Toxin        


Download         Length: 336 a.a.        Molecular weight: 38320.60 Da        Isoelectric Point: 5.5965

>T279347 WP_001262467.1 NZ_CP124320:253341-254348 [Escherichia coli]
MANCRILLTPLNERDEQRGYSTQGLKRLSGTAKLTPRLGFTRTQFVQELPRQQKGMSISGYQPKLQLVLDEGEFRVVDHQ
GNFILKPSPADFPGLAENEHATMTLMSRLGFDVPVHGLLSFAPQSEEELEYAFVIRRYDRDNKGLPVHQEQLDGAMQIMD
KYGKTGNDNEQYVSYETLARFLVAHVNDNIAFKIDLFRRIVYAWLLGNNDMHLRNFGLVYSDGLTPALAPVYDFVSVAPY
PEYFHSNYLALPLLTREEGGRELAPGFHSDYGEYIGQDFLLLGESMGLAPRLLEKLFQDIRKENAIVMETYEQSFMTQDH
IQAVLQCYRHRLGLL

Download         Length: 1008 bp

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11821.47 Da        Isoelectric Point: 6.0609

>AT279347 WP_001312177.1 NZ_CP124320:253030-253341 [Escherichia coli]
MHRRVKVLLYGQVVGELSQNDSGFLFQYAPDYHGPAISISLPVAQRQFPSEMLHPYFASLAPEGWLRQRYSQIQHRDEND
LLGMLIDNGKNLLGAIQILPWEE

Download         Length: 312 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3K2ZTB5

Antitoxin

Source ID Structure
AlphaFold DB A0A3L3HKE2

References