279343

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4963436..4964082 Replicon chromosome
Accession NZ_CP124220
Organism Klebsiella pneumoniae strain Z

Toxin (Protein)


Gene name higB Uniprot ID A0A483PC41
Locus tag QG930_RS24170 Protein ID WP_004216295.1
Coordinates 4963735..4964082 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID W8UB68
Locus tag QG930_RS24165 Protein ID WP_002920557.1
Coordinates 4963436..4963735 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QG930_RS24145 (QG930_24145) 4959642..4960400 - 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -
QG930_RS24150 (QG930_24150) 4960450..4961280 - 831 WP_004151408.1 rhomboid family intramembrane serine protease GlpG -
QG930_RS24155 (QG930_24155) 4961331..4961660 - 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
QG930_RS24160 (QG930_24160) 4961865..4963373 + 1509 WP_002920554.1 glycerol-3-phosphate dehydrogenase -
QG930_RS24165 (QG930_24165) 4963436..4963735 - 300 WP_002920557.1 helix-turn-helix transcriptional regulator Antitoxin
QG930_RS24170 (QG930_24170) 4963735..4964082 - 348 WP_004216295.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QG930_RS24175 (QG930_24175) 4964258..4966705 - 2448 WP_002920561.1 glycogen phosphorylase -
QG930_RS24180 (QG930_24180) 4966723..4968156 - 1434 WP_004889438.1 glycogen synthase GlgA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(9-87)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13606.61 Da        Isoelectric Point: 5.6749

>T279343 WP_004216295.1 NZ_CP124220:c4964082-4963735 [Klebsiella pneumoniae]
MWDVETTDTFDTWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCADNKDGMNEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10800.58 Da        Isoelectric Point: 10.1464

>AT279343 WP_002920557.1 NZ_CP124220:c4963735-4963436 [Klebsiella pneumoniae]
MATLKELMAKQSPDSQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQADNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A483PC41

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1CBF8

References