Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4606028..4606803 Replicon chromosome
Accession NZ_CP124220
Organism Klebsiella pneumoniae strain Z

Toxin (Protein)


Gene name TacT2 Uniprot ID B6ZBI6
Locus tag QG930_RS22285 Protein ID WP_004889762.1
Coordinates 4606028..4606513 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag QG930_RS22290 Protein ID WP_004150912.1
Coordinates 4606510..4606803 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QG930_RS22265 (QG930_22265) 4603191..4603904 + 714 WP_002916694.1 DUF554 domain-containing protein -
QG930_RS22275 (QG930_22275) 4604419..4604635 - 217 Protein_4344 transposase -
QG930_RS22280 (QG930_22280) 4604732..4605324 - 593 Protein_4345 hypothetical protein -
QG930_RS22285 (QG930_22285) 4606028..4606513 - 486 WP_004889762.1 GNAT family N-acetyltransferase Toxin
QG930_RS22290 (QG930_22290) 4606510..4606803 - 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
QG930_RS22295 (QG930_22295) 4607447..4608823 + 1377 WP_017879795.1 pyridoxal-phosphate dependent enzyme -
QG930_RS22300 (QG930_22300) 4608834..4609982 + 1149 WP_004889759.1 PLP-dependent aspartate aminotransferase family protein -
QG930_RS22305 (QG930_22305) 4609983..4610894 - 912 WP_017879796.1 LysR family transcriptional regulator -
QG930_RS22310 (QG930_22310) 4610992..4611594 + 603 WP_004174410.1 short chain dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 4604483..4604635 152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17585.56 Da        Isoelectric Point: 8.5144

>T279342 WP_004889762.1 NZ_CP124220:c4606513-4606028 [Klebsiella pneumoniae]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPDPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDSMMLMVTLRDLVN
A

Download         Length: 486 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT279342 WP_004150912.1 NZ_CP124220:c4606803-4606510 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A447W563

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References