279335

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 1390546..1391143 Replicon chromosome
Accession NZ_CP124220
Organism Klebsiella pneumoniae strain Z

Toxin (Protein)


Gene name higB Uniprot ID A0A9J6S5A1
Locus tag QG930_RS06600 Protein ID WP_004893639.1
Coordinates 1390546..1390863 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID R4YH91
Locus tag QG930_RS06605 Protein ID WP_004142561.1
Coordinates 1390856..1391143 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QG930_RS06585 (QG930_06585) 1386250..1387677 - 1428 WP_004176980.1 MFS transporter -
QG930_RS06590 (QG930_06590) 1387786..1388652 + 867 WP_004151823.1 helix-turn-helix transcriptional regulator -
QG930_RS06595 (QG930_06595) 1389318..1390361 + 1044 WP_004893645.1 DUF2157 domain-containing protein -
QG930_RS06600 (QG930_06600) 1390546..1390863 + 318 WP_004893639.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QG930_RS06605 (QG930_06605) 1390856..1391143 + 288 WP_004142561.1 helix-turn-helix transcriptional regulator Antitoxin
QG930_RS06610 (QG930_06610) 1391408..1392061 - 654 WP_004178896.1 oxygen-insensitive NAD(P)H nitroreductase -
QG930_RS06615 (QG930_06615) 1392181..1392549 - 369 WP_004142557.1 MmcQ/YjbR family DNA-binding protein -
QG930_RS06620 (QG930_06620) 1392549..1393130 - 582 WP_004176968.1 TetR/AcrR family transcriptional regulator -
QG930_RS06625 (QG930_06625) 1393310..1394425 + 1116 WP_012737592.1 MBL fold metallo-hydrolase -
QG930_RS06630 (QG930_06630) 1394456..1394797 + 342 WP_002893035.1 RamA family antibiotic efflux transcriptional regulator -
QG930_RS06635 (QG930_06635) 1394815..1395063 - 249 WP_002893037.1 DUF1158 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-88)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12100.35 Da        Isoelectric Point: 11.2767

>T279335 WP_004893639.1 NZ_CP124220:1390546-1390863 [Klebsiella pneumoniae]
MFRLVVHVDVKKELQALPSIVQAKMIRQLDKLRQNPTALREPDSKPLGQGLFEIRALGSVQGRGIYVFQQGKTLFLLRVF
VKKTQKTPSSEIRLALKRLEEMRNE

Download         Length: 318 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10771.46 Da        Isoelectric Point: 10.2212

>AT279335 WP_004142561.1 NZ_CP124220:1390856-1391143 [Klebsiella pneumoniae]
MSKKIIDWDTLKTELLGQPEVQAAFDAQERQQRLRTMLAQWREQAGLTRAQVAQRMGVSAPTVSRMEANITRASLDTLTR
YALACGIKHPQVLLY

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0S3DIQ1

References