279331

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 583648..584294 Replicon chromosome
Accession NZ_CP124220
Organism Klebsiella pneumoniae strain Z

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag QG930_RS02750 Protein ID WP_038808066.1
Coordinates 583648..583998 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QG930_RS02755 Protein ID WP_038808067.1
Coordinates 583995..584294 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QG930_RS02725 (QG930_02725) 579191..579418 + 228 WP_071703920.1 hypothetical protein -
QG930_RS02730 (QG930_02730) 579411..580313 + 903 WP_038808064.1 integrase -
QG930_RS02735 (QG930_02735) 580541..581809 + 1269 WP_038808065.1 tyrosine-type recombinase/integrase -
QG930_RS02740 (QG930_02740) 581832..582017 + 186 WP_071703921.1 AlpA family phage regulatory protein -
QG930_RS02745 (QG930_02745) 582101..583147 + 1047 WP_071703922.1 helicase RepA family protein -
QG930_RS02750 (QG930_02750) 583648..583998 + 351 WP_038808066.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QG930_RS02755 (QG930_02755) 583995..584294 + 300 WP_038808067.1 XRE family transcriptional regulator Antitoxin
QG930_RS02760 (QG930_02760) 584803..585449 + 647 WP_253612655.1 IS1 family transposase -
QG930_RS02765 (QG930_02765) 585610..586188 + 579 WP_038808072.1 hypothetical protein -
QG930_RS02770 (QG930_02770) 586433..587692 + 1260 WP_049006514.1 integrase arm-type DNA-binding domain-containing protein -
QG930_RS02775 (QG930_02775) 587940..588167 + 228 WP_017880136.1 helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 578559..618825 40266
- flank IS/Tn - - 585072..585449 377


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-80)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13662.61 Da        Isoelectric Point: 6.9801

>T279331 WP_038808066.1 NZ_CP124220:583648-583998 [Klebsiella pneumoniae]
MWTVLFSQRFDDWLSEQDDALQEKVLADLGKLQVYGPELPRPYADTLKGSRYKNMKELRIQFSGQPIRAFYAFDPIRRAI
VLCAGYKSNDKRFYEKLIRIAEDEFAAHLQNLEINQ

Download         Length: 351 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11193.07 Da        Isoelectric Point: 5.1767

>AT279331 WP_038808067.1 NZ_CP124220:583995-584294 [Klebsiella pneumoniae]
MRTLDDVIAARSPESQARIKEMSDEMILEVGLQMMREELQLSQKYVAEMMGVSQPAITQLEQRGNDLKLATLKRYIEAMG
GKLSLDVELPTGKRIAFHI

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References