Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3562969..3563644 Replicon chromosome
Accession NZ_CP124121
Organism Enterobacter hormaechei strain 2020CK-00198

Toxin (Protein)


Gene name higB Uniprot ID A0A837FDC1
Locus tag QIW35_RS16880 Protein ID WP_015571638.1
Coordinates 3562969..3563268 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A2J0PXC9
Locus tag QIW35_RS16885 Protein ID WP_015571639.1
Coordinates 3563279..3563644 (+) Length 122 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QIW35_RS16870 (QIW35_16870) 3559346..3561538 + 2193 WP_039269968.1 type I secretion system permease/ATPase -
QIW35_RS16875 (QIW35_16875) 3561519..3562718 + 1200 WP_017382757.1 HlyD family efflux transporter periplasmic adaptor subunit -
QIW35_RS16880 (QIW35_16880) 3562969..3563268 + 300 WP_015571638.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QIW35_RS16885 (QIW35_16885) 3563279..3563644 + 366 WP_015571639.1 HigA family addiction module antitoxin Antitoxin
QIW35_RS16890 (QIW35_16890) 3563671..3564852 - 1182 WP_017382758.1 PLP-dependent aminotransferase family protein -
QIW35_RS16895 (QIW35_16895) 3564873..3565760 - 888 WP_015571641.1 LysR family transcriptional regulator -
QIW35_RS16900 (QIW35_16900) 3565858..3566460 + 603 WP_017382759.1 short chain dehydrogenase -
QIW35_RS16905 (QIW35_16905) 3566457..3567188 - 732 WP_039269965.1 class I SAM-dependent methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - luxS 3559346..3613314 53968


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(25-72)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11624.29 Da        Isoelectric Point: 9.6776

>T279322 WP_015571638.1 NZ_CP124121:3562969-3563268 [Enterobacter hormaechei]
MINHFRDQWLEDFFLYGRSSNVIPLNLETALARKLDIINAAMSHLDLRSPPGNMYEALSPPLKGYSSIRVNRQYRLVFRW
SEGKADDLYLSPHKYTQHK

Download         Length: 300 bp

Antitoxin


Download         Length: 122 a.a.        Molecular weight: 13705.73 Da        Isoelectric Point: 9.5936

>AT279322 WP_015571639.1 NZ_CP124121:3563279-3563644 [Enterobacter hormaechei]
MTLQQALRKPTTPGEVLQYEYLEPLNLKINDLAEMLNVHRNTVSALVNNNRKLTADMAIKLAKAFNTTIEFWLNLQLNVD
IWEAQSNSRTQEELSRIKTVAEVMAKRKSGKPDVTLHGNSA

Download         Length: 366 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FDC1

Antitoxin

Source ID Structure
AlphaFold DB A0A2J0PXC9

References