Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 16109..16760 Replicon plasmid pAb4294
Accession NZ_CP123992
Organism Acinetobacter baumannii strain Ab4294

Toxin (Protein)


Gene name higB Uniprot ID S3SZA7
Locus tag QE150_RS00085 Protein ID WP_000269903.1
Coordinates 16109..16465 (+) Length 119 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QE150_RS00090 Protein ID WP_001140619.1
Coordinates 16458..16760 (+) Length 101 a.a.

Genomic Context

QE150_RS00055QE150_RS00060QE150_RS00065QE150_RS00075QE150_RS00085QE150_RS00090QE150_RS00095QE150_RS00135QE150_RS00050QE150_RS00070QE150_RS00080QE150_RS00100QE150_RS00105QE150_RS00110QE150_RS00115QE150_RS00120QE150_RS00125QE150_RS00130
Location: 11948..12250 (303 bp)
Type: Others
Protein ID: WP_000286963.1
Location: 12251..12532 (282 bp)
Type: Others
Protein ID: WP_000985610.1
Location: 12760..13693 (934 bp)
Type: Others
Protein ID: Protein_12
Location: 14465..14695 (231 bp)
Type: Others
Protein ID: WP_009501150.1
Location: 16109..16465 (357 bp)
Type: Toxin
Protein ID: WP_000269903.1
Location: 16458..16760 (303 bp)
Type: Antitoxin
Protein ID: WP_001140619.1
Location: 16753..16962 (210 bp)
Type: Others
Protein ID: WP_000069471.1
Location: 21397..21717 (321 bp)
Type: Others
Protein ID: WP_004704395.1
Location: 11365..11748 (384 bp)
Type: Others
Protein ID: WP_281309336.1
Location: 13757..14128 (372 bp)
Type: Others
Protein ID: WP_009501156.1
Location: 14865..15401 (537 bp)
Type: Others
Protein ID: WP_009501148.1
Location: 17087..17299 (213 bp)
Type: Others
Protein ID: WP_016653394.1
Location: 17752..19356 (1605 bp)
Type: Others
Protein ID: WP_130120076.1
Location: 19426..19761 (336 bp)
Type: Others
Protein ID: WP_004691519.1
Location: 19758..20141 (384 bp)
Type: Others
Protein ID: WP_004762545.1
Location: 20348..20893 (546 bp)
Type: Others
Protein ID: Protein_23
Location: 20821..21027 (207 bp)
Type: Others
Protein ID: WP_235824376.1
Location: 21081..21209 (129 bp)
Type: Others
Protein ID: WP_002123981.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
QE150_RS00050 (QE150_00050)11365..11748-384WP_281309336.1hypothetical protein-
QE150_RS00055 (QE150_00055)11948..12250+303WP_000286963.1type II toxin-antitoxin system RelE/ParE family toxin-
QE150_RS00060 (QE150_00060)12251..12532+282WP_000985610.1putative addiction module antidote protein-
QE150_RS00065 (QE150_00065)12760..13693+934Protein_12IS5-like element ISAba13 family transposase-
QE150_RS00070 (QE150_00070)13757..14128-372WP_009501156.1RcnB family protein-
QE150_RS00075 (QE150_00075)14465..14695+231WP_009501150.1hypothetical protein-
QE150_RS00080 (QE150_00080)14865..15401-537WP_009501148.1porin family protein-
QE150_RS00085 (QE150_00085)16109..16465+357WP_000269903.1type II toxin-antitoxin system RelE/ParE family toxinToxin
QE150_RS00090 (QE150_00090)16458..16760+303WP_001140619.1XRE family transcriptional regulatorAntitoxin
QE150_RS00095 (QE150_00095)16753..16962+210WP_000069471.1hypothetical protein-
QE150_RS00100 (QE150_00100)17087..17299-213WP_016653394.1hypothetical protein-
QE150_RS00105 (QE150_00105)17752..19356-1605WP_130120076.1IS66 family transposase-
QE150_RS00110 (QE150_00110)19426..19761-336WP_004691519.1IS66 family insertion sequence element accessory protein TnpB-
QE150_RS00115 (QE150_00115)19758..20141-384WP_004762545.1transposase-
QE150_RS00120 (QE150_00120)20348..20893-546Protein_23IS5 family transposase-
QE150_RS00125 (QE150_00125)20821..21027-207WP_235824376.1AAA family ATPase-
QE150_RS00130 (QE150_00130)21081..21209-129WP_002123981.1AAA family ATPase-
QE150_RS00135 (QE150_00135)21397..21717+321WP_004704395.1type II toxin-antitoxin system Phd/YefM family antitoxin-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmid--1..154924154924
-insideIScluster/Tn--5266..2083015564


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(13-89)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 13486.45 Da        Isoelectric Point: 7.1645

>T279310 WP_000269903.1 NZ_CP123992:16109-16465 [Acinetobacter baumannii]
MWTVITTDLFNEWLAQQDQSTQEKVLAALVVLQQQGPSLGRPLVDTVYDSKFTNMKELRVQHRGKPLRAFFAFDPLRQAI
VLCIGDKGGKKRFYKEMLDIADQQYEIHLSTLGDQSNG

Download         Length: 357 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11206.01 Da        Isoelectric Point: 6.7282

>AT279310 WP_001140619.1 NZ_CP123992:16458-16760 [Acinetobacter baumannii]
MAKTLQELLANRSPESQARIQQMADELLLETQLHLIREELEISQKELAATLGIKQPSLSAIENRGHDLKISTMKKYVEAM
GGKLRIDVELPTGKHIGFNV

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A836MG83

Antitoxin

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Source
ID
Structure
No matching records found

References