27928

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 2605946..2607372 Replicon chromosome
Accession NC_018025
Organism Desulfomonile tiedjei DSM 6799

Toxin (Protein)


Gene name higB Uniprot ID I4C5M2
Locus tag DESTI_RS10865 Protein ID WP_014810006.1
Coordinates 2605946..2606281 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID I4C5M3
Locus tag DESTI_RS10870 Protein ID WP_014810007.1
Coordinates 2606281..2607372 (+) Length 364 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DESTI_RS10845 2601348..2602493 - 1146 WP_014810003.1 cation:proton antiporter -
DESTI_RS28735 2602549..2603850 - 1302 WP_014810004.1 dynamin family protein -
DESTI_RS10855 2604251..2605519 + 1269 WP_014810005.1 DUF1311 domain-containing protein -
DESTI_RS10865 2605946..2606281 + 336 WP_014810006.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DESTI_RS10870 2606281..2607372 + 1092 WP_014810007.1 HigA family addiction module antidote protein Antitoxin
DESTI_RS10875 2607614..2608468 + 855 WP_014810009.1 DUF4238 domain-containing protein -
DESTI_RS10880 2608542..2608985 - 444 WP_014810010.1 nucleoside 2-deoxyribosyltransferase -
DESTI_RS10885 2609066..2609641 - 576 WP_014810012.1 hypothetical protein -
DESTI_RS10890 2609801..2610868 - 1068 WP_014810013.1 hypothetical protein -
DESTI_RS10895 2611321..2611509 - 189 WP_014810014.1 hypothetical protein -
DESTI_RS10900 2611937..2612263 + 327 WP_041286133.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-81)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(15-89)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13125.14 Da        Isoelectric Point: 10.3545

>T27928 WP_014810006.1 NC_018025:2605946-2606281 [Desulfomonile tiedjei DSM 6799]
MDIDFKSKKLMKIFNSEERLRKEYGPEQARLIQRRMWILRAAPTLADVPTDKPERRHQLKGDRKNQFAVDLKQPFRLIFE
PNHNPIPRSEDGNIITSNVTAITILEVKDYH

Download         Length: 336 bp

>T27928 NC_018025:2605946-2606281 [Desulfomonile tiedjei DSM 6799]
ATGGATATAGATTTCAAGTCTAAGAAATTGATGAAGATTTTCAACTCAGAGGAACGTCTTCGCAAAGAATACGGTCCCGA
GCAAGCGCGACTCATCCAAAGGCGGATGTGGATACTTCGCGCCGCACCAACGCTTGCAGATGTACCGACCGATAAGCCAG
AGCGAAGACACCAACTGAAAGGGGACAGGAAAAATCAATTTGCCGTGGATTTGAAACAACCGTTTCGGCTTATTTTTGAG
CCAAACCATAATCCTATTCCGAGGTCAGAAGACGGTAATATCATCACCAGTAACGTCACTGCGATTACGATACTGGAAGT
AAAGGACTATCACTGA

Antitoxin


Download         Length: 364 a.a.        Molecular weight: 41503.56 Da        Isoelectric Point: 9.3778

>AT27928 WP_014810007.1 NC_018025:2606281-2607372 [Desulfomonile tiedjei DSM 6799]
MITQTANKFTPDYVISPGEILEETLEARGIKKKEFAERCGLSDKTVSLIIHGKAPVLPETAIQFERVLGVSAAIWNNLEA
AYRLHHANKAEQDKLNTQRQWAKRFPVNELAKRGFIEKPDDAIDAVRKLLNFFAVASIEIWEKRYASMLVAYRHSPSFKS
APEAVATWLRIGELVAERIETAPYSRDTFLAALNQIRSLTSSSDFEHKMKTLCQEAGIALVFVPEFKNTRLSGATRWLTK
DKALIILSLRHKRDDHLWFSFFHESAHILHHGKKETFLDEKDTPESDQEKEADAFAADFLIPAKSYRDFIKNKIFSEKSI
RLFAEQQGIAPGIIVGRLQRDKQITYGSLNHLKRVFEFKTEIS

Download         Length: 1092 bp

>AT27928 NC_018025:2606281-2607372 [Desulfomonile tiedjei DSM 6799]
ATGATCACACAAACAGCCAATAAATTTACTCCGGATTATGTCATATCACCTGGAGAAATTCTTGAGGAAACCCTCGAGGC
GCGGGGGATCAAAAAGAAAGAATTCGCCGAACGATGCGGCCTCTCGGATAAGACTGTAAGTCTCATAATTCACGGGAAAG
CTCCAGTTCTACCAGAAACAGCTATCCAGTTTGAGCGGGTGCTGGGGGTCTCCGCGGCAATATGGAACAACCTTGAAGCC
GCGTATCGTTTACACCATGCCAACAAAGCCGAACAAGATAAACTCAATACTCAGCGGCAATGGGCGAAACGTTTCCCTGT
CAATGAGCTCGCCAAAAGAGGGTTTATAGAAAAGCCGGACGATGCAATTGATGCCGTCAGGAAGCTCTTGAATTTCTTCG
CTGTCGCGTCAATAGAAATTTGGGAGAAGCGCTATGCTTCCATGCTTGTGGCATATAGGCATTCTCCGTCCTTCAAGAGC
GCACCCGAAGCTGTAGCTACCTGGTTGAGAATAGGGGAACTGGTGGCAGAAAGAATAGAAACTGCACCATATTCCAGAGA
TACCTTTCTTGCTGCCTTGAATCAGATAAGAAGTTTAACAAGCTCATCCGATTTTGAACATAAAATGAAGACACTTTGCC
AAGAAGCCGGCATAGCATTAGTTTTTGTGCCAGAATTTAAGAATACGCGTCTCAGTGGCGCAACACGTTGGCTCACAAAG
GACAAAGCGCTGATCATCCTCAGTCTTCGCCACAAAAGAGATGATCATTTGTGGTTCAGTTTCTTTCACGAGTCTGCCCA
CATTTTGCACCACGGGAAAAAAGAGACATTTCTGGACGAGAAAGACACACCTGAAAGTGATCAAGAAAAAGAAGCGGATG
CTTTTGCAGCGGACTTCTTGATACCTGCCAAGAGTTATCGTGATTTCATAAAGAATAAAATCTTTTCCGAAAAATCAATC
AGGTTATTTGCTGAACAGCAAGGCATAGCACCTGGAATAATCGTTGGGAGACTCCAACGAGACAAACAGATTACATATGG
TAGCCTCAATCATCTAAAAAGAGTCTTTGAATTCAAGACAGAAATTTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB I4C5M2

Antitoxin

Source ID Structure
AlphaFold DB I4C5M3

References